Special Issue "Astroglial Connexin Physiology"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 December 2019).
Interests: astrocytes; glia; connexins; gliovascular unit; blood-brain barrier; local translation; neuropathologies
Astrocytes are key active elements of the brain that contribute to information processing. Astrocytes closely interact with neurons and provide them with metabolic and structural support. They regulate neurogenesis, brain wiring, synaptic activity, and plasticity. Astrocytes also interact with brain vessels and control blood-brain barrier integrity, immunity, and blood flow. Dysfunction of astrocytes can induce major alterations in neuronal and vascular functions, contributing to the pathogenesis of several brain disorders. A typical feature of astrocytes compared to other brain cell populations is their high level of Connexin (Cx) expression with two major Cxs: Cx43 and Cx30. Cxs assemble in gap junction channels permeable to ions and small signaling molecules allowing direct cell-to-cell communication and providing the basis for intercellular pathways between large populations of astrocytes. Cxs also work as hemichannels and play a paracrine role by allowing exchanges between the cytoplasm and the extracellular medium. Finally, besides these channel functions, Cxs play adhesive and signaling functions. Astroglial Cxs are implicated in a wide variety of processes. They contribute to neurotransmission, endowing neurons with an optimal state to process information. They also control BBB integrity and immune surveillance. Determining how astroglial Cxs confers specific features and functions to astrocytes and their role in brain physiology is a key issue that we propose to develop in this Special Issue of Cells.
Dr. Martine Cohen-Salmon
Manuscript Submission Information
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- gap junctions