Investigating Male Reproductive System through Animal Model

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 1344

Special Issue Editor


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Guest Editor
School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong, China
Interests: cell junction structure; junction dynamics; germ cell migration; signalling; transcription; ubiquitination

Special Issue Information

Dear Colleagues,

Reproductive issues pertaining to infertility have been often perceived as female-related problems. In fact, one third of infertility cases are solely caused by male reproductive issues. Research on the male reproductive system has not only uncovered the fundamental process of spermatogenesis, but also helps to unravel the causes of male infertility. This Special Issue entitled “Investigating Male Reproductive System through Animal Models” is intended to untangle the contribution of animal models in exploring various functions of the male reproductive system.

This Special Issue will examine the importance of various animal models ranging from primitive multicellular to mammalian models in unraveling testis development, the molecular mechanisms of spermatogenesis, sperm epigenetics and infertilty, as well as the endocrine aspects of the male reproductive system. Manuscripts that report original research and comprehensive reviews will be considered.

Dr. Wing Yee Lui
Guest Editor

Manuscript Submission Information

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Keywords

  • male infertility
  • spermatogenesis
  • testis development
  • sperm epigenetics
  • male reproductive system
  • animal model

Published Papers (1 paper)

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Research

15 pages, 2802 KiB  
Article
The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia Reperfusion Injury
by Abdullah Alnajem and May Al-Maghrebi
Cells 2023, 12(18), 2292; https://doi.org/10.3390/cells12182292 - 16 Sep 2023
Viewed by 1111
Abstract
The male reproductive system requires the pleiotropic activity of JAK/STAT to maintain its function, especially spermatogenesis. The study aims to investigate the effect of JAK2 signaling on the expression of the Keap1/Nrf2 axis, spermatogenesis, and the Sertoli cells (Sc) junctions in an animal [...] Read more.
The male reproductive system requires the pleiotropic activity of JAK/STAT to maintain its function, especially spermatogenesis. The study aims to investigate the effect of JAK2 signaling on the expression of the Keap1/Nrf2 axis, spermatogenesis, and the Sertoli cells (Sc) junctions in an animal model of testicular ischemia reperfusion injury (tIRI). Testes subjected to tIRI exhibited increased JAK2/STAT3 activity associated with spermatogenic arrest and reduced expression of the Sc junctions. In addition, there was an increased protein expression of Keap1 and decreased Nrf2., which was coupled with the downregulation of gene expression of antioxidant enzymes. Reduced SOD and CAT activities were accompanied by increased lipid peroxidation and protein carbonylation during tIRI. Increased caspase 9 activity and Bax/Bcl2 ratio indicated initiation of apoptosis. Inhibition of JAK2 activity by AG490 maintained the integrity of spermatogenesis and SC junctions, normalized the expression of the Keap1/Nrf2 axis and its downstream antioxidant enzymes, and prevented germ cell apoptosis. The results further emphasized the regulatory role of JAK2/STAT3 on spermatogenesis, Keap1/Nrf2 signaling, and maintenance of the testicular redox balance to combat testicular dysfunction and male infertility. Full article
(This article belongs to the Special Issue Investigating Male Reproductive System through Animal Model)
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