Special Issue "Epigenetic Regulation of Stem Cells Ageing in Health and Disease"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 October 2018).

Special Issue Editor

Dr. Dagmara McGuinness
E-Mail Website
Guest Editor
Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
Institute of Cancer Sciences, University of Glasgow (Affiliate), Glasgow, UK
Interests: ageing; longevity; epigenetics; metabolism; diseases of ageing

Special Issue Information

Dear Colleagues,

Stem cell function drives normal organismal function, development, and growth; as such, their roles in ageing, as well as in health and disease, are similarly critical. Understanding the mechanisms associated with stem cell functional decline, which accompanies ageing processes, both physiologically and pathologically, will lead to a greater understanding of the tissue-specific, as well as the overall changes at the systemic level that contribute to organismal ageing. Furthermore, these mechanisms are likely to underpin many of the diseases of ageing, in fact stem cell involvement has already been demonstrated in many diseases. The underlying mechanisms of ageing and disease, in relation to stem cells, are of particular interest in the wake of recent discoveries underlining the importance of epigenetic regulation of ageing processes, particularly when viewed in the context of development of novel therapeutic interventions.

The rate of ageing can be affected by multiple factors, both intrinsic and environmental, that affect stem cells directly or indirectly resulting in far reaching and long lasting effects leading to changes disease occurrence or progression. Many of the diseases regarded as increasing threats, particularly to the western societies, are caused or accelerated by stem cell ageing. It is therefore timely to take a close look at the mechanisms behind this. With epigenetic modifications leading the way as candidates for directing or initiating these changes it is pertinent to investigate these modifications and determine their influence of the development and progression of disease, as well as their role in directing stem cell function and ageing.

The aim of this Special Issue is to summarize and expand the current knowledge on the epigenetic regulation of stem cells and the influence of these modifications on the incidence and progression of diseases associated with ageing. Furthermore, this Special Issue seeks to open the discussion on recent developments, focusing on the role of epigenetics in the regulation of stem cells ageing in health and disease, with particular emphasis on changes associated with ageing.

Dr. Dagmara McGuinness
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • ageing
  • epigenetics
  • metabolism
  • health and disease

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Open AccessReview
Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
Cells 2018, 7(12), 268; https://doi.org/10.3390/cells7120268 - 12 Dec 2018
Cited by 12
Abstract
Skin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal [...] Read more.
Skin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic stresses, including telomere shortening, overproduction of reactive oxygen species, diet, and sunlight exposure. Epigenetic mechanisms directly regulate skin homeostasis and regeneration, but they also mark cell senescence and the natural and pathological aging processes. Progeroid syndromes represent a group of clinical and genetically heterogeneous pathologies characterized by the accelerated aging of various tissues and organs, including skin. Skin cells from progeroid patients display molecular hallmarks that mimic those associated with naturally occurring aging. Thus, investigations on progeroid syndromes strongly contribute to disclose the causal mechanisms that underlie the aging process. In the present review, we discuss the role of epigenetic pathways in skin cell regulation during physiologic and premature aging. Full article
(This article belongs to the Special Issue Epigenetic Regulation of Stem Cells Ageing in Health and Disease)
Show Figures

Figure 1

Open AccessReview
Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging
Cells 2018, 7(12), 237; https://doi.org/10.3390/cells7120237 - 29 Nov 2018
Cited by 5
Abstract
In complex organisms, stem cells are key for tissue maintenance and regeneration. Adult stem cells replenish continuously dividing tissues of the epithelial and connective types, whereas in non-growing muscle and nervous tissues, they are mainly activated upon injury or stress. In addition to [...] Read more.
In complex organisms, stem cells are key for tissue maintenance and regeneration. Adult stem cells replenish continuously dividing tissues of the epithelial and connective types, whereas in non-growing muscle and nervous tissues, they are mainly activated upon injury or stress. In addition to replacing deteriorated cells, adult stem cells have to prevent their exhaustion by self-renewal. There is mounting evidence that both differentiation and self-renewal are impaired upon aging, leading to tissue degeneration and functional decline. Understanding the molecular pathways that become deregulate in old stem cells is crucial to counteract aging-associated tissue impairment. In this review, we focus on the epigenetic mechanisms governing the transition between quiescent and active states, as well as the decision between self-renewal and differentiation in three different stem cell types, i.e., spermatogonial stem cells, hematopoietic stem cells, and muscle stem cells. We discuss the epigenetic events that channel stem cell fate decisions, how this epigenetic regulation is altered with age, and how this can lead to tissue dysfunction and disease. Finally, we provide short prospects of strategies to preserve stem cell function and thus promote healthy aging. Full article
(This article belongs to the Special Issue Epigenetic Regulation of Stem Cells Ageing in Health and Disease)
Show Figures

Graphical abstract

Open AccessReview
Extracellular Vesicles, Ageing, and Therapeutic Interventions
Cells 2018, 7(8), 110; https://doi.org/10.3390/cells7080110 - 18 Aug 2018
Cited by 7
Abstract
A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals. One exciting novel strategy that has emerged to intervene involves the use of extracellular [...] Read more.
A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals. One exciting novel strategy that has emerged to intervene involves the use of extracellular vesicles to engender tissue regeneration. Specifically, this employs their molecular payloads to confer changes in the epigenetic landscape of ageing cells and ameliorate the loss of functional capacity. Understanding the biology of extracellular vesicles and the specific roles they play during normative ageing will allow for the development of novel cell-free therapeutic interventions. Hence, the purpose of this review is to summarise the current understanding of the mechanisms that drive ageing, critically explore how extracellular vesicles affect ageing processes and discuss their therapeutic potential to mitigate the effects of age-associated morbidities and improve the human health span. Full article
(This article belongs to the Special Issue Epigenetic Regulation of Stem Cells Ageing in Health and Disease)
Show Figures

Figure 1

Back to TopTop