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Cells 2018, 7(12), 268; https://doi.org/10.3390/cells7120268

Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases

1
Istituto di Genetica Molecolare CNR, Pavia; via Abbiategrasso 207, 27100 Pavia, Italy
2
Molecular and Cell Biology Laboratory, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy
*
Authors to whom correspondence should be addressed.
Received: 15 November 2018 / Revised: 7 December 2018 / Accepted: 11 December 2018 / Published: 12 December 2018
(This article belongs to the Special Issue Epigenetic Regulation of Stem Cells Ageing in Health and Disease)
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Abstract

Skin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic stresses, including telomere shortening, overproduction of reactive oxygen species, diet, and sunlight exposure. Epigenetic mechanisms directly regulate skin homeostasis and regeneration, but they also mark cell senescence and the natural and pathological aging processes. Progeroid syndromes represent a group of clinical and genetically heterogeneous pathologies characterized by the accelerated aging of various tissues and organs, including skin. Skin cells from progeroid patients display molecular hallmarks that mimic those associated with naturally occurring aging. Thus, investigations on progeroid syndromes strongly contribute to disclose the causal mechanisms that underlie the aging process. In the present review, we discuss the role of epigenetic pathways in skin cell regulation during physiologic and premature aging. View Full-Text
Keywords: skin; stem cells; epigenetic mechanisms; aging; progeroid syndromes; premature aging syndromes skin; stem cells; epigenetic mechanisms; aging; progeroid syndromes; premature aging syndromes
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Orioli, D.; Dellambra, E. Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases. Cells 2018, 7, 268.

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