Role of Bioactive Peptides and Their Receptors in the Adrenal Gland and Adrenocortical Carcinoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (10 December 2021) | Viewed by 4385
Special Issue Editor
Special Issue Information
Dear Colleagues,
Both physiological and pathophysiological functions of the adrenal gland are regulated by a complex network of endocrine and/or autocrine/paracrine interactions. In this context, it is well known that glucocorticosteroids stimulate NPY release by hypothalamic neurons, with simultaneous inhibition of CRH and MCH secretion. Apart from classical adrenocortical secretagogues such as angiotensin 2 and corticotropin, recently, a large group of biologically active peptides that are involved in the control of the growth, morphogenesis, and function of the adrenal gland was identified. Among these peptides, adropin was shown to stimulate proliferation and to inhibit adrenocortical steroidogenesis in a primary human adrenal carcinoma cell culture and in a human adrenocortical carcinoma cell line, acting via GPR19 receptor activation. Another peptide, nesfatin, is expressed in the human adrenal gland and in an adrenal cell line derived from a carcinoma. Stimulation with nesfatin inhibits proliferation and promotes apoptosis, potentially via the involvement of Bax, BCL-XL, and BCL-2 genes as well as ERK1/2, p38, and JNK1/2 signaling cascades. Adropin and nesfatin are just two examples of a large group of biologically active peptides acting on adrenal gland’s functions. It should be mentioned that this group includes classic and widely studied peptides mainly associated with feeding behaviour, such as orexin, leptin, ghrelin, and adiponectin. Another classical example is IGF2, a mitogenic peptide hormone whose overexpression occurs in adrenocortical carcinoma and which is associated with a poor prognosis.
This Special Issue of Cells is devoted to all aspects of bioactive peptides’ effects on physiological and pathophysiological functions of the adrenal cortex. It will present articles that collectively provide a balanced, state-of-the-art view of the role of bioactive peptides on adrenal gland’s functions. We encourage authors to send high-quality reviews and papers describing the results of original studies in the above-mentioned areas of research.
Prof. Dr. Marcin RucinskiGuest Editor
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Keywords
- bioactive peptides
- adrenal gland
- adrenocortical carcinoma
- HPA-axis
- G protein-coupled receptor
- hormones
- steroidogenesis
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