New Insights on Intercellular Pathways in Pulmonary Arterial Hypertension: Emerging and Alternative Approaches

Dear Colleagues,

Pulmonary arterial hypertension is a progressive and fatal condition, characterized by functional and structural alterations of the pulmonary circulation and, if left untreated, resulting in increased pulmonary vascular resistance, elevated pulmonary arterial pressures and, eventually, right ventricular failure and death. Despite access to several medications developed over the past three decades, the disease remains incurable, with room to improve its prognosis. Currently available drugs fail to reverse pulmonary vascular remodelling driven by intricate molecular and cellular mechanisms involving resident vascular cells, circulating inflammatory cells and the extracellular matrix. Emerging approaches allowing for an alternative to in vivo animal models may offer novel perspectives in order to decipher these subtle cellular–matrix interactions.

The purpose of this Special Issue is to focus on alternative approaches to achieve comprehensible knowledge regarding recently identified mechanisms involved in the progression of pulmonary arterial hypertension, aiming to reverse vascular remodelling to open up future and innovative treatment options and strategies.

Consequently, we warmly invite the community to submit original articles or reviews covering the above mentioned field.

We look forward to your contributions. 

Dr. Rozenn Quarck
Guest Editor

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• pulmonary arterial hypertension
• inflammation
• angiogenesis
• endothelium
• extra cellular matrix
• vascular remodelling