The Contribution of Proteomics to Chromatin Biology and Epigenetic Research
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 292
Special Issue Editors
2. Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy
Interests: histone post-translational modifications; mass spectrometry; chromatin proteomics; SILAC; gene expression regulation; methyl-proteome; epigenetic drugs, cancer epigenetics, clinical proteomics, epigenetic biomarkers
Interests: spectrometry-based proteomics; proteomics; proteomics and epigenetic profiling of clinical samples; novel epigenetic biomarkers and targetable pathways in cancer
Special Issue Information
Dear Colleagues,
Approximately 20,000 protein-encoding genes exist in every cell in our bodies. The use of these genes to generate a variety of existing cells types and to mediate different cellular responses to environmental stimuli is determined by epigenetic information. Epigenetic features, including histones, which allow DNA wrapping and compaction into chromatin, exist in several variants and are modified by a number of reversible post-translational modifications. Histone modifications and variants contribute to the regulation of gene expression by affecting chromatin compaction and by recruiting downstream effectors, which translate the epigenetic information into biological outcomes. Aberrations in this complex machinery can lead to diseased states, and can be targeted to restore physiological conditions.
Thanks to its unbiased nature, comprehensiveness, and quantitative accuracy, mass spectrometry (MS)-based proteomics have emerged as a versatile and powerful tool to study epigenetic mechanisms, from histone post-translational modifications and variants, to chromatin-associated factors. In this Special Issue, entitled “The contribution of proteomics to chromatin biology and epigenetic research”, we seek contributions (original research articles and methods) that exploit MS-based proteomics technologies to investigate epigenetic mechanisms. Perspectives and reviews on this subject are also welcome.
Prof. Dr. Tiziana Bonaldi
Dr. Roberta Noberini
Guest Editors
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Keywords
- chromatin
- histone post-translational modifications
- histone variants
- mass spectrometry
- proteomics
- epigenetic modifiers
- histone PTM readers
- epigenetic drug target deconvolution
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