Special Issue "Structure and Function of Podoplanin (PDPN) in Disease"
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 13887
Interests: monoclonal antibody (mAb); antibody therapy; podoplanin (PDPN); cancer-specific mAb (CasMab); anti-glycopeptide mAb (GpMab); cell-based immunization and screening (CBIS)
Podoplanin (PDPN), also known as T1alpha or Aggrus, is a type I transmembrane sialoglycoprotein that is expressed not only in normal tissues, such as pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells, but also in cancer tissues, including brain tumor, malignant mesothelioma, oral cancer, and lung cancer. PDPN is associated with tumor cell-induced platelet aggregation and hematogenous metastasis through interactions with the C-type lectin-like receptor 2 (CLEC-2). Recent clinical studies have shown the association between increased PDPN expression and poor disease prognosis, indicating that the establishment of anti-PDPN mAbs is critical for developing novel therapeutic strategies against cancer development and metastatic progression. This Special Issue of Cells should improve our understanding of PDPN by including researchers working not only with structure and function of PDPN but also diagnosis and therapy targeting PDPN, including antibody-drug conjugate (ADC), chimeric antigen receptor-T (CAR-T) therapy, radioimmunotherapy (RIT), photoimmunotherapy (PIT), and liquid biopsy.
Prof. Yukinari Kato
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- podoplanin (PDPN)
- platelet aggregation