Pathogenesis of Autoimmune Neuronal Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 6414
Special Issue Editor
Special Issue Information
Dear Colleagues,
The study of autoimmune neurological diseases constitutes an exciting and expanding field. Since the initial description of anti-NMDAR antibodies in 2007 by Dr. Josep Dalmau, the identification of novel antibodies and target autoantigens has experienced an almost exponential increase, and syndromes previously considered idiopathic, untreatable, or misdiagnosed can now be recognized and properly categorized, and patients can receive efficient treatments. Neuronal antibodies are associated with different syndromes, but their contribution to the pathogenesis and the central nervous system dysfunction is highly dependent on whether the antigen is extracellular or intracellular. Those antibodies directed against cell-surface targets are more likely to be pathogenic (NMDAR, LGI1, CASPR2, etc.), and those directed to intracellular antigens (Hu, Yo, Ri, amphiphysin, Ma2 etc.) are more likely to reflect a T-cell-mediated response and neuronal damage. We now know that these disorders can be triggered by tumors, can be post-infectious like the post-herpetic NMDAR encephalitis, or can even be caused by immune-checkpoint inhibitor therapy. Recently, an intriguing connection between autoimmune disorders, neuroinflammation, and neurodegeneration has started to be established. Anti-IgLON5 disease is the perfect example of this link, where patients have autoantibodies against IgLON5 but also evidence of neurodegeneration.
This Special Issue aims to gather different aspects of these interesting autoimmune neurological disorders, review the knowledge about their pathogenesis, and collect new interesting biomarker studies.
We are pleased to invite you to collaborate with an original research article or a review about the topic.
Dr. Lidia Sabater
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune encephalitis
- neuroinflammation
- neurodegeneration
- immune checkpoint inhibitors
- animal models
- organoids
- IPSCs
- biomarkers
