Viral Nuclear Transport: From Molecular Pathogenesis to Antiviral Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 10933
Special Issue Editor
Interests: nucleo-cytoplasmic shuttling; protein–protein interactions; antiviral drug discovery; viral replication
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Viruses intensively interact with the host cell nucleocytoplasmic nuclear transport apparatus at different levels. Indeed, viral proteins can be actively translocated across the nuclear pore complex or interfere with the cellular nucleocytoplasmic transport process itself. These events are crucial for viral genome nuclear targeting, expression, replication, and encapsidation, as well as for host cell function manipulation, with profound effects on cell proliferation, survival, and antiviral response. Furthermore, recent developments of broad and specific nuclear transport inhibitors suggest a potential future pharmacological implication for antiviral drug discovery.
This Special Issue will welcome original research and review articles dealing with functional, biochemical, and structural aspects on the subject, including the following topics:
- Nucleocytoplasmic trafficking of viral proteins;
- Interaction of viral proteins with cellular transporters;
- Nuclear delivery and egress of viral genomes;
- Modulation of the nuclear pore function and composition during viral infection;
- Delocalization of nucleoporins to viral replication factories;
- Antiviral implications of nucleocytoplasmic transport inhibitors.
Dr. Gualtiero Alvisi
Guest Editor
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