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Cells
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Nuclear Lamina in Health and Disease
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Nuclear Lamina in Health and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3150

Special Issue Editors

Prof. Dr. Igor Kireev

E-Mail Website
Guest Editor
Department Electron Microscopy, A.N.Belozersky Institute of Physico-chemical Biology, Moscow State University, Vorobjevi Gory, 119899 Moscow, Russia
Interests: nuclear architecture; higher order chromosome organization; chromatin-nuclear envelope interactions; spatial organization of DNA synthesis
Dr. Kundan Sengupta

E-Mail Website
Guest Editor
Indian Institute of Science Education and Research Pune, Pune, Maharashtra, India
Interests: chromosomes; nucleus; cancer; mechanosignalling; aneuploidy; chromatin; genome integrity; epigenetics

Special Issue Information

Dear Colleagues,

The nuclear lamina is a protein meshwork of intermediate filaments that envelop the nucleus and protect the genome. While mutations in lamins are associated with progeria, muscular dystrophies and cancers, lamins are involved in regulating a multitude of cellular functions. These functions range from genome organization, DNA damage repair, chromosomal stability, gene expression, transcriptional regulation and the cell cycle. Considering the unique subcellular localization of nuclear lamins at the border of the nucleus and cytosol, lamins interact with proteins of the linker to nucleoskeleton and cytoskeleton (LINC) complex that, in turn, is closely associated with the cytoskeleton. Therefore, cells are remarkably sensitive to mechanical forces that emanate from its immediate outside environment that are relayed via integrins into the nuclear envelope and nuclear lamins. Interestingly, mutations in the LINC or lamins are associated with a plethora of diseases including cancers, ciliopathies, envelopathies and laminopathies. Therefore, therapeutic approaches and targets to repair an injured nucleus are of paramount importance for cell survival. 

This Special Issue on lamins in health and disease of the journal Cells presents a gamut of cutting-edge, state-of-the-art findings on the treasure trove that lamins beckon us to unravel.

Prof. Dr. Igor Kireev
Dr. Kundan Sengupta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lamina
  • LINC
  • laminopathies
  • mechanotransduction
  • transcription regulation
  • epigenetics
  • genome organization

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Published Papers (1 paper)

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11 pages, 279 KiB  
Opinion
The Paradox of Nuclear Lamins in Pathologies: Apparently Controversial Roles Explained by Tissue-Specific Mechanobiology
by Enrica Urciuoli and Barbara Peruzzi
Cells 2022, 11(14), 2194; https://doi.org/10.3390/cells11142194 - 13 Jul 2022
Cited by 5 | Viewed by 2304
Abstract
The nuclear lamina is a complex meshwork of intermediate filaments (lamins) that is located beneath the inner nuclear membrane and the surrounding nucleoplasm. The lamins exert both structural and functional roles in the nucleus and, by interacting with several nuclear proteins, are involved [...] Read more.
The nuclear lamina is a complex meshwork of intermediate filaments (lamins) that is located beneath the inner nuclear membrane and the surrounding nucleoplasm. The lamins exert both structural and functional roles in the nucleus and, by interacting with several nuclear proteins, are involved in a wide range of nuclear and cellular activities. Due their pivotal roles in basic cellular processes, lamin gene mutations, or modulations in lamin expression, are often associated with pathological conditions, ranging from rare genetic diseases, such as laminopathies, to cancer. Although a substantial amount of literature describes the effects that are mediated by the deregulation of nuclear lamins, some apparently controversial results have been reported, which may appear to conflict with each other. In this context, we herein provide our explanation of such “controversy”, which, in our opinion, derives from the tissue-specific expression of nuclear lamins and their close correlation with mechanotransduction processes, which could be very different, or even opposite, depending on the specific mechanical conditions that should not be compared (a tissue vs. another tissue, in vivo studies vs. cell cultures on glass/plastic supports, etc.). Moreover, we have stressed the relevance of considering and reproducing the “mechano-environment” in in vitro experimentation. Indeed, when primary cells that are collected from patients or donors are maintained in a culture, the mechanical signals deriving from canonical experimental procedures of cell culturing could alter the lamin expression, thereby profoundly modifying the assessed cell type, in some cases even too much, compared to the cell of origin. Full article
(This article belongs to the Special Issue Nuclear Lamina in Health and Disease)
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