New Paradigms in Cardioprotection
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 157
Special Issue Editor
Special Issue Information
Dear Colleagues,
“…..after 50 years of intense basic and clinical research, we still lack an intervention that can be applied to patients with STEMI to achieve limitation of infarct size beyond that afforded by reperfusion alone” [1]. There is a growing awareness that the abject failure to translate the myriad purportedly promising cardioprotective strategies identified in preclinical models to the clinical setting may reflect a failure to consider the host of confounding comorbidities manifest in patients suffering from acute myocardial infarction, together with a lack of rigor in the design of studies conducted in animal models. New paradigms in cardioprotection are therefore required that address the need to conduct experiments that utilize preclinical models displaying clinically relevant comorbidities (for example, increased age, diabetes, co-medications, etc.) and are performed with the highest standards of scientific rigor, as established by the CAESAR consortium [2].
This Special Issue aims to provide a forum for the publication of original research articles that meet these robust criteria. Preclinical studies must have clear translational relevance, and clinical studies are welcome. Review papers providing novel insights into the challenges of developing effective cardioprotective strategies will also be considered on a selective basis.
References
- Bolli R, Tang XL. Basic Res Cardiol. 2022;117:57. doi: 10.1007/s00395-022-00964-1.
- Jones SP, Tang XL, Guo Y et al., Circ Res 2015;116:572-86. doi: 10.1161/CIRCRESAHA.116.305462.
Prof. Dr. Karin Przyklenk
Guest Editor
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Keywords
- myocardial ischemia–reperfusion injury
- infarct size
- preconditioning
- postconditioning
- remote ischemic conditioning
- aging
- diabetes
- metabolic syndrome
- hypercholesterolemia
- genetic variation
- co-medications
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