Chronic Skin Wound Healing and Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 135
Special Issue Editor
Special Issue Information
Dear Colleagues,
The dynamic regulation of cytoskeletal proteins underpins many of the processes fundamental to wound healing and tissue repair. Changes in cellular structure drive migration, growth, and differentiation, with the cytoskeleton acting as the crucial link between the cells’ exterior and intracellular signalling. The complex cascade of highly controlled and conserved cellular and molecular processes to achieve tissue repair involves numerous cell types and extracellular matrix molecules regulated by the actin cytoskeleton. This dynamic scaffold translates external cues from extracellular matrix stiffness and growth factors into internal responses. However, in chronic wounds, its function becomes disrupted, resulting in stalled healing; genes controlling cytoskeletal dynamics are altered, hindering cell movement and proper tissue remodelling, contributing to the persistent inflammation and breakdown seen in these difficult-to-heal wounds. Moreover, the interaction between the cytoskeletal proteins and extracellular matrix drives fibrosis, with cytoskeletal proteins released during tissue damage a key driver of inflammation. The identification of cytoskeletal targets that can be used to manipulate and improve wound healing is included as an emerging area of focus that may inform future therapeutic approaches to improve the healing of complex wounds.
We invite submissions for research articles, reviews, and communications that fall under the following umbrellas of research areas:
- Targeting cytoskeletal proteins to promote regenerative healing;
- Actin cytoskeleton dysfunction as a mediator of diabetic complications;
- Cytoskeletal signalling and inflammatory dysregulation in chronic wounds;
- Extracellular actin scavenging system (EASS) in trauma, inflammation, and chronic wounds;
- Interaction between cytoskeletal proteins and extracellular matrix during fibrosis.
Dr. Xanthe Venn
Guest Editor
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Keywords
- actin cytoskeleton
- inflammation
- chronic wounds
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