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Cells
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Ion Channels in Non-excitable Cells
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Ion Channels in Non-excitable Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 15285

Special Issue Editors

Dr. Csaba Matta

E-Mail Website
Guest Editor
Department of Anatomy, Histology & Embryology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Egyetem tér 1, Hungary
Interests: chondrogenesis; ion channels; calcium signalling; circadian rhythm; mechanotransduction; osteoarthritis
Dr. Eiva Bernotiene

E-Mail Website
Guest Editor
Department of Regenerative, State Research Institute Centre for Innovative Medicine (IMC), Vilnius, Lithuania
Interests: human cartilage; chondrocytes; mesenchymal stem cells; chondrogenesis; ion channels; osteoarthritis; mechanotransduction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The plasma membrane of cells in the musculoskeletal system harbors a rich and diverse complement of membrane proteins, collectively referred to as the membranome, which defines the cell surface phenotype and identity of the cells. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal, and ECM proteins and other macromolecular complexes. The membranome is important for the function of the cells and is a key target of pharmacological interventions. The channelome is a subcompartment of the membranome and comprises a complete set of ion channels and porins. Environmental factors such as excessive and inappropriate mechanical load or an inflammatory microenvironment can result in a modified channelome and a subsequently altered ionic homeostasis in the cells of the musculoskeletal system, impairing its function. This is an important and relatively unexplored aspect of the complex and poorly understood mechanism of musculoskeletal disease development, especially in non-excitable cells such as chondrocytes, osteocytes, tenocytes, and synoviocytes, as well as mesenchymal stem cells. This Special Issue offers an Open Access forum that aims to bring together a collection of original research and review articles addressing the expanding field of ion channel research in non-excitable cells. We hope to provide a stimulating resource for the fascinating subject of musculoskeletal research. Suggested potential topics include calcium signaling in health and disease; potassium, sodium and chloride channels; mechanotransduction and mechanosensation; and regulation of chanellome.

Dr. Csaba Matta
Dr. Eiva Bernotiene
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chondrocyte
  • osteocyte
  • tenocyte
  • synoviocyte
  • mesenchymal stem cell
  • channelome
  • calcium signalling
  • mechanotransduction

Published Papers (3 papers)

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Research

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27 pages, 5776 KiB  
Article
Ion Channel Modeling beyond State of the Art: A Comparison with a System Theory-Based Model of the Shaker-Related Voltage-Gated Potassium Channel Kv1.1
by Sonja Langthaler, Jasmina Lozanović Šajić, Theresa Rienmüller, Seth H. Weinberg and Christian Baumgartner
Cells 2022, 11(2), 239; https://doi.org/10.3390/cells11020239 - 11 Jan 2022
Cited by 6 | Viewed by 3428
Abstract
The mathematical modeling of ion channel kinetics is an important tool for studying the electrophysiological mechanisms of the nerves, heart, or cancer, from a single cell to an organ. Common approaches use either a Hodgkin–Huxley (HH) or a hidden Markov model (HMM) description, [...] Read more.
The mathematical modeling of ion channel kinetics is an important tool for studying the electrophysiological mechanisms of the nerves, heart, or cancer, from a single cell to an organ. Common approaches use either a Hodgkin–Huxley (HH) or a hidden Markov model (HMM) description, depending on the level of detail of the functionality and structural changes of the underlying channel gating, and taking into account the computational effort for model simulations. Here, we introduce for the first time a novel system theory-based approach for ion channel modeling based on the concept of transfer function characterization, without a priori knowledge of the biological system, using patch clamp measurements. Using the shaker-related voltage-gated potassium channel Kv1.1 (KCNA1) as an example, we compare the established approaches, HH and HMM, with the system theory-based concept in terms of model accuracy, computational effort, the degree of electrophysiological interpretability, and methodological limitations. This highly data-driven modeling concept offers a new opportunity for the phenomenological kinetic modeling of ion channels, exhibiting exceptional accuracy and computational efficiency compared to the conventional methods. The method has a high potential to further improve the quality and computational performance of complex cell and organ model simulations, and could provide a valuable new tool in the field of next-generation in silico electrophysiology. Full article
(This article belongs to the Special Issue Ion Channels in Non-excitable Cells)
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Review

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23 pages, 2108 KiB  
Review
Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels
by Raminta Vaiciuleviciute, Daiva Bironaite, Ilona Uzieliene, Ali Mobasheri and Eiva Bernotiene
Cells 2021, 10(10), 2572; https://doi.org/10.3390/cells10102572 - 28 Sep 2021
Cited by 16 | Viewed by 7499
Abstract
Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix [...] Read more.
Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, β-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols. Full article
(This article belongs to the Special Issue Ion Channels in Non-excitable Cells)
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23 pages, 2712 KiB  
Review
K+ and Ca2+ Channels Regulate Ca2+ Signaling in Chondrocytes: An Illustrated Review
by Yoshiaki Suzuki, Hisao Yamamura, Yuji Imaizumi, Robert B. Clark and Wayne R. Giles
Cells 2020, 9(7), 1577; https://doi.org/10.3390/cells9071577 - 29 Jun 2020
Cited by 17 | Viewed by 2945
Abstract
An improved understanding of fundamental physiological principles and progressive pathophysiological processes in human articular joints (e.g., shoulders, knees, elbows) requires detailed investigations of two principal cell types: synovial fibroblasts and chondrocytes. Our studies, done in the past 8–10 years, have used electrophysiological, Ca [...] Read more.
An improved understanding of fundamental physiological principles and progressive pathophysiological processes in human articular joints (e.g., shoulders, knees, elbows) requires detailed investigations of two principal cell types: synovial fibroblasts and chondrocytes. Our studies, done in the past 8–10 years, have used electrophysiological, Ca2+ imaging, single molecule monitoring, immunocytochemical, and molecular methods to investigate regulation of the resting membrane potential (ER) and intracellular Ca2+ levels in human chondrocytes maintained in 2-D culture. Insights from these published papers are as follows: (1) Chondrocyte preparations express a number of different ion channels that can regulate their ER. (2) Understanding the basis for ER requires knowledge of (a) the presence or absence of ligand (ATP/histamine) stimulation and (b) the extraordinary ionic composition and ionic strength of synovial fluid. (3) In our chondrocyte preparations, at least two types of Ca2+-activated K+ channels are expressed and can significantly hyperpolarize ER. (4) Accounting for changes in ER can provide insights into the functional roles of the ligand-dependent Ca2+ influx through store-operated Ca2+ channels. Some of the findings are illustrated in this review. Our summary diagram suggests that, in chondrocytes, the K+ and Ca2+ channels are linked in a positive feedback loop that can augment Ca2+ influx and therefore regulate lubricant and cytokine secretion and gene transcription. Full article
(This article belongs to the Special Issue Ion Channels in Non-excitable Cells)
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