Special Issue "Immuno-Metabolic Crosstalk in Oncogenesis"
Deadline for manuscript submissions: 30 September 2021.
Interests: metabolism; inflammation; immunosuppression; cancers; lipids; liver
Altered cellular metabolism and immunosuppression in the tumor microenvironment became emerging hallmarks of cancer. Oncometabolites are needed to sustain tumor cell survival, growth, and proliferation by fulfilling the energetic needs and providing the raw materials and signaling molecules for many oncogenic pathways. Some are capable of driving immune cell polarization toward immunosuppressive and cancer-tolerant isotypes. The main focus of this Special Issue is the crosstalk between these two hallmarks in the context of oncogenesis. Decoding this subtle crosstalk at the molecular and cellular levels is a prerequisite for the discovery of more effective combinatory therapeutic approaches targeting immuno-metabolism of cancers.
I am seeking all topics relevant to metabolic defect, adaptation, nutritional addiction of cancer cells, and modulation of tumor-targeted immune responses.
I am looking forward to receiving your contribution.
Prof. Aksam J. Merched
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- immune resolution
- nutritional dependence
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Gliomas: relationship between metabolism and microenvironment
Authors: Ainhoa Hernández; Ana M. Muñoz-Mármol; Cristina Carrato; Marta Domenech; Carmen Balana
Affiliation: 1Institut Catala d’Oncologia (ICO) Badalona, Badalona Applied Research Group in Oncology (B- ARGO Group), Institut Investigació Germans Trias i Pujol (IGTP), Badalona, Spain 2Pathology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Title: Tumour metabolism in myeloid-driven immunosuppression
Authors: Thomas Boyer1; Céline Blaye1,2; Nicolas Larmonier1,3; Charlotte Domblides1,4
Affiliation: 1. CNRS UMR5164, ImmunoConcEpT, Bordeaux, France 2. Department of Medical Oncology, Bergonie Institute, Bordeaux, France 3. Department of Life and Medical Sciences, University of Bordeaux, Bordeaux, France 4. Department of Medical Oncology, Hôpital Saint-André, University Hospital Bordeaux, France
Abstract: Tumour metabolism plays a crucial role in sustaining tumorigenesis. Increasing reports highlight the role of tumour metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture leading to immune escape. The metabolic reprogramming of tumour cells and the immune escape are two major hallmarks of cancer, with several cross talks between them. Here, we propose to review the effect of tumour metabolism on immune cells focusing on myeloid-cells, due to their important role in tumorigenesis and immunosuppression, from the early stages of the disease. We will also discuss about ways to target this specific crosstalk in cancer patients.
Title: Immuno-metabolic modulation of liver oncogenesis by the tryptophan
Authors: Véronique Trézéguet-Busquet; Hala Fatrouni; Aksam Merched
Affiliation: Bordeaux University and Inserm U 1035, Biotherapy of Genetic, Inflammatory Diseases and Cancer (BMGIC), MiRCade Team; Bordeaux, France.
Abstract: Metabolic rewiring in tumor cells is a major hallmark of oncogenesis. Some of the oncometabolites drive suppressive and tolerogenic signals from the immune system, which becomes complicit to the advent and the survival of neoplasia. Tryptophan catabolism through the kynurenin (Kyn) pathway was reported to play immunosuppressive actions across many types of cancer. Extensive debate of whether the culprit of immunosuppression was the depletion of Trp or rather Kyn accumulation in the tumor microenvironment has been ongoing for years. Results from clinical trials assessing the benefit of inhibiting key limiting enzymes of this pathway such as indoleamine 2,3-dioxygenase (IDO1) failed to meet the expectations. Bearing in mind the complexity of the tumoral terrain and the existence of different cancers with IDO1/TDO expressing and non-expressing tumoral cells, here we present a comprehensive analysis of the trp global metabolic hub and the driving potential of the process of oncogenesis with main focus on liver cancers.