Special Issue "Glycosylation and Deglycosylation in Animal Development"
Deadline for manuscript submissions: 31 August 2021.
Interests: glycosylation; N-glycanase 1; Notch signaling; BMP signaling; AMPK signaling
Special Issues and Collections in MDPI journals
Over the last two decades, it has become clear that glycosylation, which is the addition of carbohydrates to proteins and other biological molecules, plays critical roles in animal development. At least 1 in 50 human genes encodes proteins that directly or indirectly contribute to glycosylation. Moreover, it is estimated that around half of the proteins in a given cell are glycosylated. In keeping with these numbers, mutations in genes involved in glycosylation and deglycosylation play a causative role in more than 130 human diseases, affecting various tissues and organ systems. Importantly, new techniques in molecular biology, genetics, and genome engineering have helped scientists to identify specific roles for multiple forms of glycosylation in modulating the activity of various developmental signaling pathways. In addition, advances in glycomics and glycoproteomics have increasingly enabled us to learn the proteome-wide and protein/site-specific distribution of glycans in various cell types in health and disease. As a result, the field of developmental glycobiology has shown a rapid growth in recent years, both in terms of number of papers published and in terms of the depth of analysis now possible in these studies. The present Special Issue aims to highlight some of the major advances in this field. Contributions to this collection can be primary research articles or review articles discussing how the addition or removal of glycans from proteins or lipids can impact metazoan development and/or human diseases. I invite colleagues to submit articles covering the roles of glycans as seen through the lenses of structural biology, cellular biology, model organisms, and/or human disease pathophysiology.Dr. Hamed Jafar-Nejad
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- developmental biology
- developmental signaling pathways
- nucleocytoplasmic glycosylation
- model organism research
- congenital disorders of glycosylation
- glycosyl hydrolase
- nucleotide sugar transporter
- mass spectrometry
- structural biology