Exploring the Cellular Basis of Steatotic Liver Disease: Insights and Advances
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 718
Special Issue Editor
Interests: metabolic dysfunction-associated steatotic liver disease (MASLD); inflammatory liver disease; biomarkers; liver fibrosis; macrophages
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a leading cause of chronic liver disease worldwide, with its progression ranging from simple steatosis to more severe conditions such as metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. Despite its prevalence, the cellular mechanisms underlying MASLD and its progression are still not fully understood. This Special Issue of Cells aims to explore recent insights into the cellular basis of fatty liver disease, shedding light on the complex interplay between hepatocytes, hepatic stellate cells, Kupffer cells, and immune cells in the context of lipid metabolism, inflammation, and fibrosis. Furthermore, this Special Issue will highlight advanced in vitro and in vivo models and discuss novel biomarkers and potential therapeutic strategies targeting cellular pathways to mitigate disease progression.
We invite contributions that cover cellular signaling, lipid metabolism, mitochondrial dysfunction, oxidative stress, and the role of the gut–liver axis, offering new perspectives on both the pathogenesis and potential therapeutic avenues for NAFLD.
Yours faithfully,
The Guest Editor
Prof. Dr. Henning Gronbaek
Guest Editor
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Keywords
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- hepatocytes
- hepatic stellate cells
- lipid metabolism
- inflammation
- fibrosis
- mitochondrial dysfunction
- Kupffer cells
- the microbiome
- the gut–liver axis
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