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New Advances in Molecular, Cellular, and Biobehavioral Studies on Neuro-Psychiatric...
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New Advances in Molecular, Cellular, and Biobehavioral Studies on Neuro-Psychiatric Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 3525

Special Issue Editors

Dr. Lee Wei Lim

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Guest Editor
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Interests: neuromodulation; depression; dementia; cellular and molecular neuroscience
Special Issues, Collections and Topics in MDPI journals
Dr. Luca Aquili

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Guest Editor
College of Health and Education, Discipline of Psychology, Murdoch University, Perth 6150, Australia
Interests: neuropsychology; cognition; cellular and molecular neuroscience
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tatyana Strekalova

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Guest Editor
Department of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands
Interests: neuroscience; biobehavior; mood and anxiety disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neuropsychiatric diseases have undergone decades of research, but cellular mechanisms related to these disorders are complicated and dynamic, making them difficult to fully delineate. A previous Special Issue, entitled “Current Approaches of Molecular and Biobehavioral Studies on Neuro-Psychiatric Diseases”, was very successful, publishing eight papers and reviews concerning various aspects of neuropsychiatric diseases.

The purpose of this Special Issue is to highlight recent findings that shed light on current approaches of cutting-edge molecular techniques on biobehavioral functions in neurological and psychiatric diseases. This issue targets molecular, cellular, and biochemical methods to identify disease biomarkers and study the neural circuits and pathogenesis of the central nervous system, specifically focusing on neurological disorders, mood and anxiety disorders, schizophrenia, autism, and others.

In particular (but not exclusively), this Special Issue invites contributions that report on:

  • Studies related to the pathophysiology and basic mechanisms of neuropsychiatric diseases;
  • The current approaches of cutting-edge cellular and molecular neurobiology, including state-of-the-art neurochemistry, neuropharmacology, neural genetics, optogenetic, chemogenetic, CRISPR-Cas9, etc.;
  • Biological activity and neuropharmacology studies on behavioral and neural phenotypes.

We welcome the submission of both original research articles and reviews. All scientists working in these fields are cordially invited to submit their manuscripts. All papers will be published on an ongoing basis with full open access. We look forward to receiving your interesting contributions.

Dr. Lee Wei Lim
Dr. Luca Aquili
Prof. Dr. Tatyana Strekalova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurochemistry
  • neuropharmacology
  • biobehavioral
  • neurology
  • neuropsychiatry

Published Papers (2 papers)

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Research

30 pages, 5678 KiB  
Article
Repetitive Transcranial Magnetic Stimulation Reduces Depressive-like Behaviors, Modifies Dendritic Plasticity, and Generates Global Epigenetic Changes in the Frontal Cortex and Hippocampus in a Rodent Model of Chronic Stress
by David Meneses-San Juan, Mónica Lamas and Gerardo Bernabé Ramírez-Rodríguez
Cells 2023, 12(16), 2062; https://doi.org/10.3390/cells12162062 - 14 Aug 2023
Cited by 2 | Viewed by 1405
Abstract
Depression is the most common affective disorder worldwide, accounting for 4.4% of the global population, a figure that could increase in the coming decades. In depression, there exists a reduction in the availability of dendritic spines in the frontal cortex (FC) and hippocampus [...] Read more.
Depression is the most common affective disorder worldwide, accounting for 4.4% of the global population, a figure that could increase in the coming decades. In depression, there exists a reduction in the availability of dendritic spines in the frontal cortex (FC) and hippocampus (Hp). In addition, histone modification and DNA methylation are also dysregulated epigenetic mechanisms in depression. Repetitive transcranial magnetic stimulation (rTMS) is a technique that is used to treat depression. However, the epigenetic mechanisms of its therapeutic effect are still not known. Therefore, in this study, we evaluated the antidepressant effect of 5 Hz rTMS and examined its effect on dendritic remodeling, immunoreactivity of synapse proteins, histone modification, and DNA methylation in the FC and Hp in a model of chronic mild stress. Our data indicated that stress generated depressive-like behaviors and that rTMS reverses this effect, romotes the formation of dendritic spines, and favors the presynaptic connection in the FC and DG (dentate gyrus), in addition to increasing histone H3 trimethylation and DNA methylation. These results suggest that the antidepressant effect of rTMS is associated with dendritic remodeling, which is probably regulated by epigenetic mechanisms. These data are a first approximation of the impact of rTMS at the epigenetic level in the context of depression. Therefore, it is necessary to analyze in future studies as to which genes are regulated by these mechanisms, and how they are associated with the neuroplastic modifications promoted by rTMS. Full article
(This article belongs to the Special Issue New Advances in Molecular, Cellular, and Biobehavioral Studies on Neuro-Psychiatric Diseases)
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22 pages, 3500 KiB  
Article
Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms
by Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel and Lee Wei Lim
Cells 2023, 12(11), 1449; https://doi.org/10.3390/cells12111449 - 23 May 2023
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Abstract
High-frequency stimulation (HFS) is a promising therapy for patients with depression. However, the mechanisms underlying the HFS-induced antidepressant-like effects on susceptibility and resilience to depressive-like behaviors remain obscure. Given that dopaminergic neurotransmission has been found to be disrupted in depression, we investigated the [...] Read more.
High-frequency stimulation (HFS) is a promising therapy for patients with depression. However, the mechanisms underlying the HFS-induced antidepressant-like effects on susceptibility and resilience to depressive-like behaviors remain obscure. Given that dopaminergic neurotransmission has been found to be disrupted in depression, we investigated the dopamine(DA)-dependent mechanism of the antidepressant-like effects of HFS of the prelimbic cortex (HFS PrL). We performed HFS PrL in a rat model of mild chronic unpredictable stress (CUS) together with 6-hydroxydopamine lesioning in the dorsal raphe nucleus (DRN) and ventral tegmental area (VTA). Animals were assessed for anxiety, anhedonia, and behavioral despair. We also examined levels of corticosterone, hippocampal neurotransmitters, neuroplasticity-related proteins, and morphological changes in dopaminergic neurons. We found 54.3% of CUS animals exhibited decreased sucrose consumption and were designated as CUS-susceptible, while the others were designated CUS-resilient. HFS PrL in both the CUS-susceptible and CUS-resilient animals significantly increased hedonia, reduced anxiety, decreased forced swim immobility, enhanced hippocampal DA and serotonin levels, and reduced corticosterone levels when compared with the respective sham groups. The hedonic-like effects were abolished in both DRN- and VTA-lesioned groups, suggesting the effects of HFS PrL are DA-dependent. Interestingly, VTA-lesioned sham animals had increased anxiety and forced swim immobility, which was reversed by HFS PrL. The VTA-lesioned HFS PrL animals also had elevated DA levels, and reduced p-p38 MAPK and NF-κB levels when compared to VTA-lesioned sham animals. These findings suggest that HFS PrL in stressed animals leads to profound antidepressant-like responses possibly through both DA-dependent and -independent mechanisms. Full article
(This article belongs to the Special Issue New Advances in Molecular, Cellular, and Biobehavioral Studies on Neuro-Psychiatric Diseases)
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