Adipose-Derived Mesenchymal Stem Cells in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 4935
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adipose-derived stem cells (ASCs) are a subtype of mesenchymal stem cells. ASCs have recently garnered increasing interest for use in potential cellular therapies. The primary advantages of ASCs compared to other mesenchymal stem cells (MSCs) include them being easily obtained (in an autologous manner) from only slightly invasive procedures, rendering a large number of multipotent stem cells with the potential to differentiate into several cellular lineages, showing immunomodulatory properties, and promoting tissue regeneration by a paracrine action through the secretion of extracellular vesicles that contain trophic factors.
Studies conducted both in vitro and in vivo have demonstrated that ASCs are multipotent, possessing the ability to differentiate into cells of mesodermal origins, including adipocytes, chondrocytes, osteoblasts, and others. Moreover, ASCs produce a broad array of cytokines, growth factors, nucleic acids (miRNAs), and other macromolecules into the surrounding milieu via secretion or in the context of microvesicles. The secretome of ASCs has been shown to alter tissue biology, stimulate tissue-resident stem cells, change immune cell activity, and mediate therapeutic outcomes.
Researchers working in the field of regenerative medicine and immunological-related pathways are encouraged to publish their recent findings in this Special Issue of Cells.
Dr. Spencer A. Brown
Guest Editor
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Keywords
- adipose-derived stem cells (ASCs)
- multipotent stem cells
- extracellular vesicles
- cellular therapy
- tissue regeneration
- immunoregulation