Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances

Dear Colleagues,

Peritoneal malignancies represent a formidable challenge in oncology, and a comprehensive understanding of their intricate cellular and molecular underpinnings is necessary in order to develop more refined therapeutic strategies. Recent advancements in molecular biology, immunology, and surgical innovation have significantly enhanced our ability to detect, classify, and treat peritoneal metastases with greater precision. However, further exploration is crucial in deciphering the complex interplay within the tumor microenvironment and optimizing treatment paradigms.

This Special Issue will reveal the cellular and molecular mechanisms driving peritoneal carcinomatosis and translate these insights into pioneering therapeutic approaches. We welcome contributions exploring, but not limited to, the following areas:

• The cellular and molecular pathways orchestrating peritoneal metastases;
• Tumor microenvironment dynamics and their influence on therapeutic resistance;
• The immunological dimensions of peritoneal malignancies and novel immunotherapeutic strategies;
• Molecular intraperitoneal treatment strategies for precision-guided treatment (e.g., based on Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC));
• The development and clinical utility of molecular-based peritoneal surface area quantification tools;
• The role of cellular metabolism and epigenetic regulation in peritoneal tumor progression and therapeutic response;
• Experimental models and preclinical investigations to analyze emerging therapeutic agents;
• Novel biomarkers and risk stratification frameworks to optimize patient selection for cytoreductive surgery and intraperitoneal chemotherapy.

We invite the submission of original research articles, reviews, and communications that contribute to the evolving molecular understanding and clinical management of peritoneal malignancies. By launching this Special Issue, we aim to provide a dynamic platform for cutting-edge research, fostering interdisciplinary collaboration and propelling innovation in this complex and rapidly advancing field.

Dr. Tarkan Jäger
Dr. Ibrahim Büdeyri
Dr. Jan Philipp Ramspott
Guest Editors

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• peritoneal metastasis
• cytoreductive surgery
• HIPEC
• PIPAC
• biomarker
• tumor microenvironment
• epigenetics
• precision oncology
• tumor metabolism
• immunotherapy