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Cells
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The Transmission, Pathogenesis and Immune Defense of Zoonotic Diseases
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The Transmission, Pathogenesis and Immune Defense of Zoonotic Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3784

Special Issue Editors

Prof. Dr. Liancheng Lei

E-Mail Website
Guest Editor
Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China
Interests: pathogen infection; immune defense; immunological pathogenesis; vaccine and antibody products
Prof. Dr. Na Li

E-Mail Website
Guest Editor
Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China
Interests: infection and immunology; pathogenesis and immune mechanisms; big data; control and prevention of zoonosis

Special Issue Information

Dear Colleagues,

A zoonotic disease is any of a group of diseases that can naturally transmit between humans and vertebrate animals. It not only affects animal life safety but also seriously threatens human public health. There are over 200 known types of zoonoses as reported by WHO. Moreover, the number of emerging and re-emerging zoonoses is gradually increasing as time goes on. Zoonotic pathogens can be viruses, bacteria, fungi, etc., which enter the host, replicate, destroy the immune response, spread to target organs, and establish the infection of the target organs. This process involving the pathogens, host stromal/immune cells, and their interaction can lead to tissue injury and transmission of the disease. Future studies to understand the transmission, pathogenesis and immune defense of zoonotic diseases are critically important to prevent and control zoonosis.

This Special Issue of Cells therefore invite you to contribute the review articles, or original research articles on all aspects related to “The Transmission, Pathogenesis and Immune Defense of Zoonotic Diseases”. Relevant topics include, but are not limited to:

  •  Identification of pathogenic factors of pathogens and their interoperability mechanism with hosts;
  •  Immune response against infection including key immune cell types, cytokines, chemokines, and immune signaling pathways;
  •  Novel strategies for treatment and diagnosis of zoonosis.

Prof. Dr. Liancheng Lei
Prof. Dr. Na Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

13 pages, 5757 KiB  
Article
Upregulation of TLR4-Dependent ATP Production Is Critical for Glaesserella parasuis LPS-Mediated Inflammation
by Fei Liu, Yidan Gao, Jian Jiao, Yuyu Zhang, Jianda Li, Luogang Ding, Lin Zhang, Zhi Chen, Xiangbin Song, Guiwen Yang, Jiang Yu and Jiaqiang Wu
Cells 2023, 12(5), 751; https://doi.org/10.3390/cells12050751 - 26 Feb 2023
Cited by 2 | Viewed by 1750
Abstract
Glaesserella parasuis (G. parasuis), an important pathogenic bacterium, cause Glässer’s disease, and has resulted in tremendous economic losses to the global swine industry. G. parasuis infection causes typical acute systemic inflammation. However, the molecular details of how the host modulates the [...] Read more.
Glaesserella parasuis (G. parasuis), an important pathogenic bacterium, cause Glässer’s disease, and has resulted in tremendous economic losses to the global swine industry. G. parasuis infection causes typical acute systemic inflammation. However, the molecular details of how the host modulates the acute inflammatory response induced by G. parasuis are largely unknown. In this study, we found that G. parasuis LZ and LPS both enhanced the mortality of PAM cells, and at the same time, the level of ATP was enhanced. LPS treatment significantly increased the expressions of IL-1β, P2X7R, NLRP3, NF-κB, p-NF-κB, and GSDMD, leading to pyroptosis. Furthermore, these proteins’ expression was enhanced following extracellular ATP further stimulation. When reduced the production of P2X7R, NF-κB-NLRP3-GSDMS inflammasome signaling pathway was inhibited, and the mortality of cells was reduced. MCC950 treatment repressed the formation of inflammasome and reduced mortality. Further exploration found that the knockdown of TLR4 significantly reduced ATP content and cell mortality, and inhibited the expression of p-NF-κB and NLRP3. These findings suggested upregulation of TLR4-dependent ATP production is critical for G. parasuis LPS-mediated inflammation, provided new insights into the molecular pathways underlying the inflammatory response induced by G. parasuis, and offered a fresh perspective on therapeutic strategies. Full article
(This article belongs to the Special Issue The Transmission, Pathogenesis and Immune Defense of Zoonotic Diseases)
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13 pages, 9910 KiB  
Article
Genome Assessment of Carbapenem- and Colistin-Resistant Escherichia coli from Patients in a Sentinel Hospital in China
by Jiangang Ma, Biao Tang, Jiahui Lin, Abdelaziz Ed-Dra, Hui Lin, Jing Wu, Yuzhi Dong, Hua Yang and Min Yue
Cells 2022, 11(21), 3480; https://doi.org/10.3390/cells11213480 - 3 Nov 2022
Cited by 5 | Viewed by 1616
Abstract
Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 E. coli strains from [...] Read more.
Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 E. coli strains from patients between January and July 2021. One blaNDM-1-, nine blaNDM-5-, and one mcr-1-positive E. coli recovered from inpatients were identified as resistant to meropenem and colistin. There are 37 virulence genes discovered in the 11 strains, including astA in strain EC21Z-147 (O128: H4), which belongs to the enteroaggregative E. coli (EAEC). The blaNDM gene is distributed into distinct ST types, including ST48, ST616, ST410, ST711, and ST2003, while the mcr-1 gene was identified in ST117. The conjugative plasmids IncX3, IncI1-I, and IncI2 mediated the blaNDM-5 and mcr-1 genes detected among inpatients. Notably, the youngest age at which mcr-1-positive E. coli has been reported was at one day old, in a child in which the strain is closely related to strains with animal origins. Hospitals are major environments for the spread and dissemination of critical virulence and AMR genes, which requires active monitoring systems at the genome level to surveil the spread of virulence and AMR. Full article
(This article belongs to the Special Issue The Transmission, Pathogenesis and Immune Defense of Zoonotic Diseases)
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