Molecular and Cellular Mechanisms on Plant Polyphenols

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Plant, Algae and Fungi Cell Biology".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 524

Special Issue Editors


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Guest Editor
Department of Biomedical, Experimental and Clinical Sciences “Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Interests: amyloid; cytotoxicity; inflammation; polyphenols
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Interests: amyloid aggregation; autophagy; natural polyphenols; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing extension in life expectancy is accompanied by a progressively greater rate of chronic diseases, most of which are still waiting for effective therapies. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets can be traced back to the presence of significant amounts of naturally occurring bioactive molecules as secondary metabolites that are naturally synthesized in plants, structurally optimized by evolution toward particular biological functions, including the regulation of endogenous defense mechanisms and interaction with other organisms. Among the enormous quantities of these bioactive molecules, polyphenols have shown a pleiotropic behavior on key proteins that act as regulators of the complex cell homeostatic systems including metabolic and redox balance, proteostasis, and inflammatory response. This Special Issue aims to bring researchers together in an open forum where researchers can share the innovative results of their investigations both in the form of original research or review papers in order to provide an overview of the current knowledge in the myriad functions and mechanisms of dietary or non-dietary polyphenols and provide a rationale for the possible use of these substances, or their molecular scaffolds, as nutraceuticals or for new drugs design. At the same time, this open forum can provide the opportunity for new collaborations and interactions with the industrial world.

Dr. Monica Bucciantini
Dr. Manuela Leri
Guest Editors

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Keywords

  • natural polyphenols
  • cell homeostasis
  • anti-oxidant
  • anti-inflammatory
  • health effects

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Published Papers (1 paper)

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Review

24 pages, 1007 KiB  
Review
Cardiovascular and Metabolic Benefits of Extra Virgin Olive Oil Phenolic Compounds: Mechanistic Insights from In Vivo Studies
by Gabriele Serreli, Anna Boronat, Rafael De la Torre, Josè Rodriguez-Moratò and Monica Deiana
Cells 2024, 13(18), 1555; https://doi.org/10.3390/cells13181555 - 16 Sep 2024
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Abstract
Extra virgin olive oil (EVOO) represents a significant source of monounsaturated fatty acids (MUFA) and vitamin E, but it is also considered a functional food, due to the content of peculiar bioactive molecules, such as phenolic compounds, being able to modulate various processes [...] Read more.
Extra virgin olive oil (EVOO) represents a significant source of monounsaturated fatty acids (MUFA) and vitamin E, but it is also considered a functional food, due to the content of peculiar bioactive molecules, such as phenolic compounds, being able to modulate various processes related to aging and the most common metabolic and degenerative diseases. A lot of experimental research has focused on some of these components, but in most cases, the studies were performed in vitro testing compounds at non-physiological concentrations and achieving results that cannot easily be translated in vivo. Recent clinical studies demonstrated that in vivo these compounds are able to regulate physiological functions and prevent several pathological events including metabolic and cardiovascular diseases (CVDs), which represent the main causes of death worldwide. This review aims to sum up the major evidence on the beneficial effects of EVOO phenolic compounds in vivo on these pathologies, describing and evaluating the efficacy in relation to the mechanisms of diseases of the whole phenolic fraction and some of its specific components. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms on Plant Polyphenols)
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