Protein Misfolded Oligomers and Neurodegenerative Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 423

Special Issue Editors

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Guest Editor
LENS-European Laboratory for Non-Linear Spectroscopy, Sesto Fiorentino, Italy
Interests: neurodegeneration; drug investigation; protein aggregation; translational research
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Guest Editor
Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Interests: amyloid aggregation; autophagy; natural polyphenols; neurodegenerative diseases
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Special Issue Information

Dear colleagues,

The conversion of peptides and proteins into highly structured fibrillar aggregates is associated with a number of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and many others. In such pathological conditions, an important cytotoxic role is thought to be played by small soluble oligomers that accumulate during the aggregation process or released by mature fibrils.

Over the years, the structural features of toxic protein oligomers, including small-size and high solvent-exposed hydrophobicity, which are responsible for aberrant interactions with cellular components, have been investigated, as well as various events that lead to neuronal dysfunction. Moreover, several potential therapeutic strategies have been explored, including small molecules, antibodies, and natural compounds, some of which exhibit promising outcomes.

This Special Issue welcomes the submission of original research papers and reviews on the most advanced developments in the above-mentioned topics, with special attention to possible therapeutic approaches targeting protein misfolded oligomers.

Dr. Claudia Capitini
Dr. Manuela Leri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • protein misfolded oligomers
  • oligomer structure
  • neurodegeneration
  • aggregation kinetics
  • neurotoxicity
  • drug discovery

Published Papers

There is no accepted submissions to this special issue at this moment.
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