Regulation of Adipogenesis and Adipocyte Function

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1539

Special Issue Editor


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Guest Editor
Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Interests: adipogenesis; white adipocytes; beige adipocytes; immunology; immune-adipocyte crosstalk; mammokines; obesity; diabetes; single cell transcriptomics

Special Issue Information

Dear Colleagues,

Unlocking the secrets of adipose depots, where white, beige, and brown adipocytes play a vital role in our metabolic health, holds the key to a healthier future. These adipocytes perform a multitude of functions that impact our overall well-being, including energy storage, dissipation, and regulation, as well as hormone and appetite control. They even produce crucial substances called adipokines and batokines, influencing our body's intricate balance of glucose, lipid, insulin, and energy balance. Recognizing the significance of maintaining a harmonious interplay between adipocyte number and function, we are presented with an unprecedented opportunity to revolutionize the treatment of obesity and diabetes.

In this Special Issue, we invite you to delve into the realm of adipogenesis and explore the intricate mechanisms governing adipocyte function, stability, and maintenance. Together, we will examine research surrounding adipocyte precursor cells and examine the profound influence of peripheral metabolic tissues (liver, muscle, etc.), the adipose tissue microenvironment, including immune cells and adipokines, on adipose health. By shedding light on the interplay between adipose thermogenesis and inter-tissue communication, we welcome research looking into uncovering anti-obesity mechanisms

Please join us as we bring together cutting-edge research that enhances our understanding of adipose tissue.

Dr. Prashant Rajbhandari
Guest Editor

Manuscript Submission Information

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Keywords

  • adipocytes
  • adipocyte precursor cells
  • adipogenesis
  • adipokines
  • batokines
  • immune cells
  • adipose tissue microenvironment
  • obesity
  • diabetes
  • adipose thermogenesis
  • animal models
  • adipocyte dysfunction

Published Papers (1 paper)

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Review

20 pages, 1368 KiB  
Review
Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition
by Marta Lopez-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde and Jose M. Arbones-Mainar
Cells 2024, 13(5), 380; https://doi.org/10.3390/cells13050380 - 22 Feb 2024
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Abstract
Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses. It comprises mainly two types: white adipose tissue (WAT) for energy [...] Read more.
Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses. It comprises mainly two types: white adipose tissue (WAT) for energy storage and brown adipose tissue (BAT) for thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, is involved in various metabolic activities, notably lipogenesis and lipolysis, critical for maintaining energy homeostasis. It also functions as an endocrine organ, secreting adipokines that influence metabolic, inflammatory, and immune processes. However, dysfunction in WAT, especially related to obesity, leads to metabolic disturbances, including the inability to properly store excess lipids, resulting in ectopic fat deposition in organs like the liver, contributing to non-alcoholic fatty liver disease (NAFLD). This narrative review delves into the multifaceted roles of WAT, its composition, metabolic functions, and the pathophysiology of WAT dysfunction. It also explores diagnostic approaches for adipose-related disorders, emphasizing the importance of accurately assessing AT distribution and understanding the complex relationships between fat compartments and metabolic health. Furthermore, it discusses various therapeutic strategies, including innovative therapeutics like adipose-derived mesenchymal stem cells (ADMSCs)-based treatments and gene therapy, highlighting the potential of precision medicine in targeting obesity and its associated complications. Full article
(This article belongs to the Special Issue Regulation of Adipogenesis and Adipocyte Function)
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