Unlocking the Gates: Multidrug Resistance Proteins—Mechanisms and Therapeutic Strategies

Dear Colleagues,

Multidrug-resistant proteins (MDRs) are membrane transporters that play a crucial role in cellular defense mechanisms against various drugs. They work by actively pumping out drugs from cells, reducing their intracellular concentration and efficacy. This resistance mechanism often involves ATP-binding cassette (ABC) transporters such as P-glycoprotein, which utilize energy from ATP hydrolysis to transport drugs across cell membranes. The application fields of MDRs are diverse and span various areas of medicine and biology such cancer treatment and infectious diseases. In pharmacology, the knowledge of MDR mechanisms is valuable for drug development and designing strategies to minimize resistance. Understanding MDRs also has implications in personalized medicine, where treatment plans can be tailored based on an individual’s susceptibility to drug resistance. The purpose of this Special Issue is to present the latest knowledge regarding the mechanisms of MDRs and how the deep understanding of this phenomenon can be used to create new therapies. We welcome original and review articles covering any aspects of this topic.

Prof. Dr. Brindusa Tiperciuc
Dr. Angela Cozma
Dr. Cezar Login
Guest Editors

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