Metabolism, Inflammation and Redox in Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 164
Special Issue Editors
Interests: microglia; Alzheimer’s disease; neurodegeneration; mitochondria
Interests: Alzheimer’s disease; astrocytes; microglia; metabolism
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease represent a growing global health challenge driven by aging populations and the lack of curative treatments. Increasing evidence highlights that metabolic dysfunction, inflammation, and redox imbalance are central drivers of neuronal vulnerability and disease progression. Mitochondrial impairment, altered glucose and lipid metabolism, oxidative stress, and disrupted antioxidant defenses are common pathological features during neurodegeneration. In parallel, metabolic rewiring of glial cells, chronic inflammation, and redox-dependent signaling pathways play crucial roles in shaping the neurodegenerative landscape.
This Special Issue, “Metabolism, Inflammation and Redox in Neurodegenerative Diseases,” aims to bring together cutting-edge research that advances our understanding of how metabolic, inflammatory, and redox mechanisms contribute to neurodegenerative processes. We welcome original research, reviews, and methodological papers exploring molecular mechanisms, experimental models, biomarkers, and potential therapeutic interventions targeting metabolic, inflammatory, and redox pathways. By integrating insights across disciplines—from biochemistry and cell biology to systems neuroscience—we hope to foster novel perspectives that may ultimately guide the development of more effective diagnostic tools and disease-modifying therapies.
Dr. Vicente Roca-Agujetas
Dr. Clara Muñoz-Castro
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial dysfunction
- redox signaling
- neurodegenerative diseases
- inflammation
- metabolic disorders
- glial metabolism
- bioenergetics
- antioxidant defenses
- metabolic reprogramming
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