Signaling Regulation of Bone and Tooth Development
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 4068
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bones and teeth belong to hard tissues. Both are formed by highly differentiated functional cells that secrete extracellular matrix and subsequently deposit crystallized minerals. However, their tissue origins, developmental processes, and corresponding signal regulatory mechanisms are quite different. Tooth development begins with the mutual induction between the dental epithelium and dental mesenchyme. This interaction continues throughout the development of the tooth crown and roots. The components of a tooth, including enamel, dentin-pulp complex, dental pulp, and cementum, each have their unique tissue structure and associated signal regulation mechanisms. The tissue origin of bone is more complex and involves both neural-crest-derived and mesoderm-derived mesenchymal cells. These cells either form cartilage as a template for endochondral ossification or directly initiate intramembranous ossification by forming ossification centers. The two types of bone formation exhibit distinct tissue morphologies and signal regulatory mechanisms along different developmental stages. The development and homeostasis of bone are also regulated by biomechanical forces, hematopoiesis, and the immune system through interactions with muscles, bone marrow, and the neurovascular system. This Special Issue aims to collect review and research articles which showcase recent advancements in understanding the signaling regulatory mechanisms of tooth and bone development, including, but not limited to, embryonic and postnatal development, tissue turnover and remodeling, matrix assembly and biomineralization, and interactions between bone and immune and endocrine systems, etc.
Dr. Xiaofang Wang
Guest Editor
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Keywords
- bone
- tooth
- osteogenesis
- odontogenesis
- enamel
- dentin
- cementum
- amelogenesis
- dentinogenesis
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