Toll-Like Receptors and Human Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 May 2025 | Viewed by 104
Special Issue Editor
Interests: toll-like receptors; antioxidants; lipid peroxidation; xenobiotics; oxidative stress; apoptosis
Special Issue Information
Dear Colleagues,
Toll-like receptors (TLRs) are a family of type I transmembrane proteins that play a critical role in immune surveillance and disease pathogenesis. Humans express ten functional TLRs (TLR1 to TLR10), whereas twelve TLRs (TLR1 to TLR9 and TLR11 to TLR13) have been identified in mice. Generally, TLRs detect multiple components released by microorganisms (pathogen-associated molecular patterns (PAMPs), dying or lytic cells (damage-associated molecular patterns (DAMPs), and chromatin-associated molecular patterns (CAMPs), thus playing a critical role not only in immune surveillance but also in disease pathogenesis. This Special Issue mainly focuses on recent research in Toll-like receptors (TLRs) and the role of their related signaling pathways in infectious (bacterial and viral infections) and non-infectious disease (neurological, metabolic, inflammation, cancer, and cardio-vascular origin) progression. The most intriguing theme of this Special Issue is the recent development of specific TLR agonists and antagonists and their effect on treating human diseases. This Special Issue provides an excellent collection of contemporary reviews and research articles covering the importance of targeting TLRs and their signaling pathways for new therapeutic drug development against human disease.
Dr. Vinothkumar Rajamanickam
Guest Editor
Manuscript Submission Information
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Keywords
- toll-like receptor
- Immune response
- infectious disease
- non-infectious disease
- targeted therapy
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