Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.9
5.1
Journals
Cells
Special Issues
Molecular Mechanisms of Exercise and Healthspan 2.0
share announcement

Molecular Mechanisms of Exercise and Healthspan 2.0

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 5924

Special Issue Editor

Dr. Robert Wessells

E-Mail Website
Guest Editor
Department of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Interests: cardiac senescence; effects of exercise-training on functional aging; insulin/TOR signaling; fatty acid transporters
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our Topical Collection "https://www.mdpi.com/journal/cells/topical_collections/Molecular_Mechanisms_Exercise_Healthspan" .

Exercise is increasingly being recognized as a broadly effective intervention for the preservation of long-term functionality during the aging process, leading to the popularization of the phrase “exercise is medicine”. Chronic exercise lowers the risk of many age-related diseases, including diabetes, heart disease, and several forms of cancer.  Exercise is also generally thought to preserve basic mobility, cognitive function, and circadian rhythms, as well as contributing to psychological health.  Despite the many benefits of chronic exercise, the mechanistic requirements for these benefits to accrue are still not fully understood and are a highly active research topic. As many patients are unable to execute demanding exercise programs, the identification of downstream mechanistic targets to deliver the benefits of chronic exercise pharmaceutically has transformative potential for the treatment of age-related disease and for the maintenance of healthy aging. In this Special Issue, we examine recent findings in diverse model systems that increase our understanding of the molecular outputs of exercise, as well as their requirements for the myriad benefits that exercise provides.

Dr. Robert Wessells
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • metabolism
  • aging
  • model systems
  • muscle
  • heart
  • adipose
  • myokine
  • nervous system
  • age-related disease

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

20 pages, 1811 KiB  
Article
Inflammation-Related Genes Are Differentially Expressed in Lipopolysaccharide-Stimulated Peripheral Blood Mononuclear Cells after 3 Months of Resistance Training in Older Women
by Lene Salimans, Keliane Liberman, Wilfried Cools, Rose Njemini, Florence Debacq-Chainiaux, Louis Nuvagah Forti, Liza De Dobbeleer, Ron Kooijman, Ingo Beyer and Ivan Bautmans
Cells 2024, 13(17), 1416; https://doi.org/10.3390/cells13171416 - 25 Aug 2024
Viewed by 1410
Abstract
Recently, we showed that three months of resistance exercise significantly alters 18 canonical pathways related to chronic inflammation in PBMCs of older adults. In this exploratory sub-study, the aim is to explore whether resistance exercise enhances the PBMCs stress response by mimicking an [...] Read more.
Recently, we showed that three months of resistance exercise significantly alters 18 canonical pathways related to chronic inflammation in PBMCs of older adults. In this exploratory sub-study, the aim is to explore whether resistance exercise enhances the PBMCs stress response by mimicking an acute infection through in vitro LPS stimulation. Women (≥65 years) were randomly divided into intensive strength training (IST), strength endurance training (SET), or flexibility training (as control group, CON) groups. PBMCs were isolated and cultured with and without LPS for 24 h. Their RNA was analyzed via targeted RNA sequencing of 407 inflammation-related genes, with relevant fold-changes defined as ≤0.67 or ≥1.5 (3 months vs. baseline). A pathway analysis using ingenuity pathway analyses identified significant pathways among 407 genes with p < 0.05 and z-scores of ≤−2 or ≥2. Fourteen women were included in the analyses. A total of 151 genes with a significant fold-change were identified. In the CON group, a less-pronounced effect was observed. Strength training altered 23 pathways in the LPS-stimulated PBMCs, none of which overlapped between the IST and SET groups. A balanced exercise program that includes both IST and SET could beneficially adapt the immune responses in older adults by inducing alterations in the inflammatory stress response of PBMCs through different genes and pathways. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Exercise and Healthspan 2.0)
►▼ Show Figures

Figure 1

14 pages, 1034 KiB  
Article
Identification of Genomic Predictors of Muscle Fiber Size
by João Paulo L. F. Guilherme, Ekaterina A. Semenova, Naoki Kikuchi, Hiroki Homma, Ayumu Kozuma, Mika Saito, Hirofumi Zempo, Shingo Matsumoto, Naoyuki Kobatake, Koichi Nakazato, Takanobu Okamoto, George John, Rinat A. Yusupov, Andrey K. Larin, Nikolay A. Kulemin, Ilnaz M. Gazizov, Edward V. Generozov and Ildus I. Ahmetov
Cells 2024, 13(14), 1212; https://doi.org/10.3390/cells13141212 - 18 Jul 2024
Cited by 4 | Viewed by 2791
Abstract
The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the [...] Read more.
The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown. The aim of our study was to determine whether 1535 genetic variants previously identified in a genome-wide association study of appendicular lean mass are associated with the CSA of fast-twitch muscle fibers (which better predict muscle strength) in the m. vastus lateralis of 148 physically active individuals (19 power-trained and 28 endurance-trained females, age 28.0 ± 1.1; 28 power-trained and 73 endurance-trained males, age 31.1 ± 0.8). Fifty-seven single-nucleotide polymorphisms (SNPs) were identified as having an association with muscle fiber size (p < 0.05). Of these 57 SNPs, 31 variants were also associated with handgrip strength in the UK Biobank cohort (n = 359,729). Furthermore, using East Asian and East European athletic (n = 731) and non-athletic (n = 515) cohorts, we identified 16 SNPs associated with athlete statuses (sprinter, wrestler, strength, and speed–strength athlete) and weightlifting performance. All SNPs had the same direction of association, i.e., the lean mass-increasing allele was positively associated with the CSA of muscle fibers, handgrip strength, weightlifting performance, and power athlete status. In conclusion, we identified 57 genetic variants associated with both appendicular lean mass and fast-twitch muscle fiber size of m. vastus lateralis that may, in part, contribute to a greater predisposition to power sports. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Exercise and Healthspan 2.0)
►▼ Show Figures

Figure 1

11 pages, 1304 KiB  
Article
n-3 Polyunsaturated Fatty Acids Are Associated with Stable Nitric Oxide Metabolites in Highly Trained Athletes
by Aleksandra Y. Lyudinina, Olga I. Parshukova and Evgeny R. Bojko
Cells 2024, 13(13), 1110; https://doi.org/10.3390/cells13131110 - 27 Jun 2024
Cited by 1 | Viewed by 1115
Abstract
Background: The aim of this study was to investigate the relationships between levels of n-3 essential polyunsaturated fatty acids (n-3 PUFAs) and stable nitric oxide (NO) metabolites in the plasma of athletes. Methods: Highly trained cross-country skiers (males, n = 39) were examined. [...] Read more.
Background: The aim of this study was to investigate the relationships between levels of n-3 essential polyunsaturated fatty acids (n-3 PUFAs) and stable nitric oxide (NO) metabolites in the plasma of athletes. Methods: Highly trained cross-country skiers (males, n = 39) were examined. The fatty acid profile of the total plasma lipids was determined by gas chromatography. The plasma NO level was studied by a colorimetric method via reaction with Griess reagent. Results: A widespread deficiency of essential n-3 PUFAs in the plasma of athletes (more than 80% of the subjects) was demonstrated in association with an imbalance in the levels of nitrates (NO3) and nitrites (NO2). A lower value of n-3 linolenic acid in the plasma (0.21 mol/%) was associated with a NO3 level below the normal range (n-3 C18:3 and NO3 Rs = 0.461; p = 0.003). Higher levels of n-3 eicosapentaenoic acid (0.8 mol/%) were associated with a concentration of NO2 above the normal value (n-3 C20:5 and NO2 Rs = 0.449; p = 0.004). Conclusion: For the first time, the participation of essential n-3 PUFAs in the nitrite–nitrate pathway of NO synthesis in highly trained skiers was demonstrated. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Exercise and Healthspan 2.0)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop