Cellular and Molecular Signaling Pathways in Matrix Remodeling in COPD
A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cell Signaling".
Deadline for manuscript submissions: 15 March 2027 | Viewed by 691
Editor
Interests: chronic obstructive pulmonary disease; extracellular matrix; lung function; asthma; acute respiratory distress syndrome; immune response in COPD
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic inflammation in COPD drives progressive structural alterations by the excessive release of proteolytic enzymes, particularly matrix metalloproteinases (MMPs), which promote degradation and remodeling of extracellular matrix (ECM) components in both the small airways and the lung parenchyma. As ECM fibers are degraded by MMP activity, the lung undergoes compensatory structural reorganization, reflecting a dynamic but often dysregulated process of repair and remodeling. Alterations in major ECM constituents, particularly collagen types I and III and elastin, are thought to play a central role in the progressive loss of tissue elasticity observed during the development of emphysema. Despite the availability of clinical and surgical strategies to control respiratory symptoms associated with these structural changes, there is currently no treatment capable of restoring damaged lung tissue. Existing therapies are limited to slowing or preventing further progression of tissue destruction. Therefore, a more comprehensive understanding of the signaling pathways involved in lung injury and remodeling during the development and progression of COPD is essential to identify new molecular targets and support the development of more effective therapeutic strategies for disease management. In this Research Topic, we welcome experimental manuscripts focusing on, but not limited to, cellular and molecular signaling pathways involved in tissue remodeling during the COPD development and progression.
Dr. Fernanda D.T.Q.S. Lopes
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- COPD
- tissue remodeling
- cellular and molecular signaling pathways
- extracellular matrix components
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
