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Cancers
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Brachytherapy in the Treatment of Gynaecological Malignancies
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Brachytherapy in the Treatment of Gynaecological Malignancies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 853

Special Issue Editor

Dr. Alina E. Sturdza

E-Mail Website
Guest Editor
Department of Radiooncology, Medical University of Vienna, 1090 Vienna, Austria
Interests: image-guided brachytherapy; gynecological malignancies; treatment of elderly patients; reirradiation; education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Brachytherapy is an essential component in the treatment of locally advanced cervical cancer, vaginal cancer and vaginal cuff recurrences post hysterectomy. Additionally, it could be used in the personalized treatment of some definitive vulvar cancers and oligo-recurrences in the vaginal cuff from ovarian cancer. Modern image-guided brachytherapy techniques using ultrasound, MRI, and CT guidance allow excellent visualization of the target and organ at risk; therefore, dose escalation with simultaneous organ spearing is possible. The therapeutic ratio with this new technology is superior to 2D brachytherapy, and this has been shown in many publications from the last 10 years. In cases of recurrence in a previously irradiated field, if other treatment modalities fail or are not available, salvage reirradiation is a very good option.

We invite you to send us your articles regarding brachytherapy in gynecological malignancies to further increase the pool of evidence about this exciting and efficient modality of treatment of gynaecological malignancies.

Dr. Alina E. Sturdza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • image-guided brachytherapy
  • gynecological malignancies
  • reirradiation using brachytherapy
  • cervical cancer
  • endometrial cancer
  • vulva/vagina cancer
  • cancer in the elderly
  • brachy education

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Published Papers (1 paper)

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Research

12 pages, 276 KB  
Article
Development of an Enomogram to Predict the Rate of Loco-Regional Control After Radio-Chemotherapy and Interventional Radiotherapy in Cervical Cancer
by Valentina Lancellotta, Maria Concetta La Milia, Rosa Autorino, Enrico Rosa, Bruno Fionda, Pierpaolo Dragonetti, Leonardo Bannoni, Raffaella Michela Rinaldi, Viola De Luca, Gerardina Stimato, Angeles Rovirosa, Alessio Giuseppe Morganti, Gabriella Macchia, Benedetta Gui, Nicolò Bizzarri, Anna Fagotti, Luca Tagliaferri and Maria Antonietta Gambacorta
Cancers 2026, 18(7), 1096; https://doi.org/10.3390/cancers18071096 - 27 Mar 2026
Viewed by 607
Abstract
Objective: This study aimed to explore the association between magnetic resonance imaging (MRI)-derived volumetric parameters and oncological outcomes, and to develop an exploratory predictive model based on these variables in patients treated with radio-chemotherapy followed by interventional radiotherapy (modern brachytherapy). Methods: [...] Read more.
Objective: This study aimed to explore the association between magnetic resonance imaging (MRI)-derived volumetric parameters and oncological outcomes, and to develop an exploratory predictive model based on these variables in patients treated with radio-chemotherapy followed by interventional radiotherapy (modern brachytherapy). Methods: Between 2021 and 2024, 300 patients with cervical cancer were included. Treatment was pelvic external beam radiotherapy with platinum-based chemotherapy followed by interventional radiotherapy boost. Volumetric MRI variables for each patient were collected. Time-to-event analyses were performed using Cox proportional hazards regression models. Model performance was assessed using Harrell’s concordance index (C-index). Internal validation was performed using bootstrap resampling. Based on the final multivariable Cox models, an interactive web-based nomogram was developed as an exploratory tool to visualize model-derived associations. Results: Median tumor volume decreased from 69.4 cm3 at diagnosis to 2.2 cm3 at the time of pre-interventional radiotherapy MRI, with a median reduction rate of 96.5%. Tumor volume at diagnosis, pre-interventional radiotherapy residual tumor volume, and tumor volume reduction rate were significantly associated with loco-regional relapse and distant metastases in Cox regression analyses. These findings were consistent across univariate and multivariable models. Internal validation confirmed the stability of the model estimates. Conclusions: MRI-derived volumetric parameters are associated with oncological outcomes in patients with locally advanced cervical cancer and may contribute to early risk stratification. The proposed model should be considered exploratory and hypothesis-generating and requires external validation before any potential clinical application. Full article
(This article belongs to the Special Issue Brachytherapy in the Treatment of Gynaecological Malignancies)
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