Dear Colleagues,

Oncologic HT is a well-known, but only partially established, therapeutic modality that is combined with systemic therapy and/or local radiotherapy in the global oncology community. Its acceptance has been slow over the last 20 years, primarily due to a lack of evidence-based preclinical and clinical research data. However, in recent years, due to advances in biology, physics, technology, and clinical oncology, its acceptance in the oncology community has grown. The reimbursement policies for oncologic hyperthermia in an increasing number of national health care systems support the recognition processes. 
The emerging complementary applications synergize different methods, increase their capabilities, and open new perspectives in the field of oncotherapies. Hyperthermia at 39°– 45°C sensitizes tumors to conventional therapies even in refractory cases, while typical other treatments promote cell distortion in addition to thermal degradation. Hyperthermia produces higher chemical reaction rates and better membrane permeability and impacts the cell cycle of the proliferating malignancy. Furthermore, hyperthermia reduces the adverse effects of conventional treatments, and its suppressed toxicity increases the patient's quality of life. 
Two main categories of local-regional hyperthermia offer heating possibilities: 
•    The homogeneous heating of the tumor mass with isothermal intent; 
•    The selective energy absorption of various inserted artificial particles (mostly nanoparticles) or selecting natural compounds in the heterogenic target. 
Intensive research covers the preclinical and clinical applications of bimodal and multimodal therapies, confirming high-level expectations. The previously observed abscopal effect of conventional treatments became a curative goal with immune activation in complementary therapy combinations, thereby opening a new perspective for advanced metastatic diseases. In this way, oncological hyperthermia provides a novel vision in immuno-oncology, extending radiotherapy from local to systemic and improving the systemic processes of various drugs. 
This Special Issue summarises results and explores the achievements and trends of research on local oncologic hyperthermia, including various heating methods. The articles explore and discuss numerous challenges and solutions, including the promising effects complementing both conventional and new oncotherapies. 

Prof. Dr. András Szász
Prof. Dr. Niloy R. Datta
Prof. Dr. Stephan Bodis
Guest Editors

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• thermoradiotherapy
• thermochemotherapy
• multimodal therapies
• resensitizing
• abscopal effect
• toxicity
• quality of life
• immune activity
• impact on metastases