Tumor Radioresistance
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 April 2019) | Viewed by 59689
Special Issue Editors
Interests: radiotherapy; hypoxia/lungcancer; metabolism; imm modulation
Special Issue Information
Dear Colleagues,
Radiotherapy is given to a majority of patients with cancer, and remains one of the most (cost)effective treatment options available. However, several mechanisms attenuating the efficacy of tumor irradiation have long been known to occur, such as hypoxia, DNA damage repair, repopulation and cell cycle redistribution. Radiobiology research into tumor radioresistance has thus focused on targeting these mechanisms to increase radiotherapy effectiveness by e.g. hypoxia modification, or using combination therapy with DNA damage repair or growth factor receptor inhibitors and reducing the overall treatment time.
The impact of some of these classic mechanisms on tumor radioresistance has changed, however, with the widespread use of novel radiotherapy regimens such as heavy ions/particles, stereotactic radiotherapy, radiotherapy and immunotherapy combination, etc.. Additionally, recent insights in additional mechanisms such as stem cells/stemness, tumor metabolism, and effect of irradiation on the immune system has lead to rapid development of additional targets for combination therapy with irradiation.
We aim to describe these new aspects identifying and overcoming tumor radioresistance in this Special Issue of Cancers, and welcome all contributions to this field.
Prof. Dr. Jan Bussink
Dr. Paul Span
Guest Editors
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Keywords
- Hypoxia
- DNA damage repair
- Metabolism
- Radiotherapy-immunotherapy combinations
- Protons
- Stem cells
- Tumor cell proliferation
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