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Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

by 1,†, 2,†, 1,3,4,5,* and 2,*
1
OncoRay–National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany
2
Laboratory of Radiobiology & Experimental Radiooncology, Department of Radiotherapy and Radiooncology, Center of Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
3
Helmholtz-Zentrum Dresden–Rossendorf, Institute of Radiooncology–OncoRay, 01328 Dresden, Germany
4
German Cancer Consortium (DKTK), Partner Site Dresden, 01307 Dresden, Germany
5
German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(6), 862; https://doi.org/10.3390/cancers11060862
Received: 17 May 2019 / Revised: 17 June 2019 / Accepted: 18 June 2019 / Published: 21 June 2019
(This article belongs to the Special Issue Tumor Radioresistance)
The current preclinical and clinical findings demonstrate that, in addition to the conventional clinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherent radioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecular mechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC research including the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironment-stimulated tumor cell reprogramming. View Full-Text
Keywords: cancer stem cells; DNA repair; radioresistance; 5Rs of radiation biology cancer stem cells; DNA repair; radioresistance; 5Rs of radiation biology
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MDPI and ACS Style

Schulz, A.; Meyer, F.; Dubrovska, A.; Borgmann, K. Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. Cancers 2019, 11, 862.

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