Novel Biomarkers of Hepatobiliary Tumors

Dear Colleagues,

Hepatobiliary tumors including hepatocellular carcinoma (HCC), intracellular cholangiocarcinoma (ICC), and extrahepatic biliary tract cancer (BTC) are lethal malignancies. They are frequently diagnosed at inoperable advanced stages so detection markers with high sensitivity and specificity are highly desired. In addition, even after curative therapy such as locoregional treatment or surgery, tumors especially HCC frequently relapse. Therefore, it is also important to develop predictive biomarkers for tumor recurrence. Several molecular targeted drugs including angiogenesis and immune checkpoint inhibitors have been recently developed but their response rates were still unsatisfactory and there are no predictive biomarkers for their efficacy. Recent technological advances are capable of using a variety of biospecimens (e.g., tissue, blood, urine, bile juice, stool and so on) and biomaterials (e.g., DNA, RNA, protein, miRNA, exosome, metabolite, circulating cells, etc) as potential biomarkers. 

For this Special Issue of Cancers, we will welcome original research and review articles that focus on recent advances in the area of biomarker research targeting hepatobiliary cancer.

Dr. Takahiro Kodama
Guest Editor

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