Mitochondria and Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 November 2019) | Viewed by 41301
Special Issue Editor
Interests: cancer immunology and biochemistry; reactive oxygen species; transplant immunology; cancer immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are indispensable for energy metabolism and are essential for the regulation of many cellular processes in healthy as well as transformed cells. Mitochondria in malignant cells differ structurally and functionally from those in normal cells, which makes them a promising target for anticancer therapy. Mitochondria in cancer cells are characterized by reactive oxygen species (ROS) overproduction, which promotes cancer development by inducing genomic instability, modifying gene expression, and participating in signaling pathways. Also, the pleiotropic roles of mitochondrial ROS in the regulation of anticancer immunity are now coming to light. The involvement of mitochondria in cancer cell metabolic reprogramming as well as in the anticancer immune response has been utilized for designing novel mitochondria-targeted anticancer agents. However, we are still far from attaining a deep understanding of the role played by mitochondria in cancer development. The main aim of this Special Issue is to collect novel findings from scientists involved in basic research as well as in translational studies in field of mitochondria and cancer.
Prof. Dr. Alexandr V. Bazhin
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- reactive oxygen species
- antioxidants
- cancer metabolisms
- tumor microenvironment
- metabolic checkpoints
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