Polyphenols and Cancer Metabolism

Dear Colleagues,

Polyphenols naturally occur in many plants, where they act as a defense mechanism against pathogens and the effects of ultraviolet light exposure. A large body of literature indicates a role for polyphenols in the prevention and control of human diseases, especially cancer and cardiovascular disease. The antioxidant and anti-inflammatory functions of polyphenols are well established; many of them interfere with the activation of Nuclear factor Kappa B (NFkB), the master control factor of inflammation. Yet polyphenols likely have additional roles in human (patho-)physiology that are not necessarily linked to anti-inflammatory functions. Several studies attribute metabolic functions to polyphenols, and they have been considered as calorie restriction mimetics.

In the present Special Issue, we would like to focus on the (anti-)metabolic activities of dietary polyphenols, which merit more attention. Metabolic derangement is a hallmark of cancer, and aerobic glycolysis provides pyruvate, the basic building block for the production of nucleic acids and proteins that is required by fast-dividing cells. Interference with the neoplastic metabolic program can contribute to cancer prevention and therapy, but the true potential of such approaches has not yet been completely revealed.

We are pleased to invite you to contribute original articles, reviews, and commentaries on the above with the aim of reflecting the state of the art in research on polyphenols and cancer metabolism. Dietary compounds and control of metabolism are much debated beyond the scientific community, and incorrect information and myths pervade public discussion. For this reason, the present Special Issue intends to make a stark statement by segregating urban legends from scientific evidence.

We look forward to receiving your contributions.

Dr. Ulrich Pfeffer
Dr. Zeinab El Rashed
Guest Editors

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