Soft Tissue Sarcoma: Imaging, Mechanisms and Therapy
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 14935
Special Issue Editors
Interests: soft tissue sarcomas; gastrointestinal stromal tumors; neuroendocrine tumors
Special Issues, Collections and Topics in MDPI journals
Interests: abdominal imaging; emergency radiology; liver imaging; pancreatic imaging; radiomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Soft tissue sarcomas are rare cancers and very heterogeneous neoplasms. For this reason, histological diagnosis is often very difficult, and the correct therapeutic approach is highly complex.
In localized disease, surgery is the standard treatment. Recently, neoadjuvant chemo-radiotherapy has been increasingly used in high-risk patients in an effort to reduce surgical morbidity and improve clinical outcomes. For this reason, imaging plays a crucial role in diagnosis and evaluation in response to treatment. Although response evaluation criteria in solid tumours (RECIST) is the most common imaging method to assess tumour response, Choi criteria and functional and molecular imaging (DWI, DCE-MRI and 18F-FDG-PET) seem to outperform it in the discrimination between responders and non-responders.
In recent years, several biological targets have been identified for new treatments, and this has changed the approach, especially in the second line of treatment. In fact, the first-line treatment of soft tissue sarcomas is well standardized, but second-line treatment can vary depending on the histotype (histology-driven treatment) and biological features. Immunotherapy has reported disappointing results, showing some activity only against some particular histologies.
In this Special Issue, experts in this field will review current approaches to the management of patients with sarcomas, and will also focus on the imaging and molecular aspects of this heterogeneous group of neoplasms.
It is with great pleasure that we introduce you to the Cancers Special Issue on “Soft Tissue Sarcomas: Imaging, Biology and Therapy”. This Special Issue aims to focus on new imaging techniques, such as radiomics, alongside the biology and treatment of these neoplasms. Original research articles on these topics are welcome; reviews are also welcome if they clarify the more complex aspects of soft tissue sarcoma management.
We look forward to receiving your contributions.
Dr. Giuseppe Badalamenti
Dr. Roberto Cannella
Dr. Andrea Napolitano
Guest Editors
Manuscript Submission Information
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Keywords
- sarcomas
- target therapy
- immunotherapy
- cancer biology
- radiomics
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