Special Issue "Non-coding RNA and Cancer"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (28 February 2013)

Special Issue Editor

Guest Editor
Prof. Peter Zaphiropoulos

Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
Website | E-Mail
Fax: +46 8 6081 501
Interests: Hedgehog signaling; epigenetics; cancer evolution; molecular targeting; non-coding RNA; circular RNA; RNA editing

Special Issue Information

Dear Colleagues,

A major challenge in our current understanding of gene expression is the finding that most of the genome is being transcribed. This results in the production of not only mRNAs with protein coding potential but also in a variety of non-coding RNA molecules. One school of thought argues that non-coding RNAs represent errors of the transcriptional apparatus, while others highlight that these molecules may have functional, but sometimes difficult to experimentally define, biological roles. In line with the latter view, evidence is accumulating for the impact of non-coding RNAs in gene transcription, translation, RNA stability, pre-mRNA splicing and chromatin structure. This special issue welcomes manuscripts that address the functional implications of short and long non-coding RNAs, with emphasis on their involvement in disease states and more specifically cancer development.

Prof. Dr. Peter Zaphiropoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gene transcription
  • RNA polymerase
  • micro RNA
  • long non-coding RNA
  • cell proliferation
  • tumor growth
  • metastasis
  • oncogene
  • tumor suppressor gene

Published Papers (1 paper)

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Review

Open AccessReview Regulatory Roles for Long ncRNA and mRNA
Cancers 2013, 5(2), 462-490; https://doi.org/10.3390/cancers5020462
Received: 1 March 2013 / Revised: 5 April 2013 / Accepted: 19 April 2013 / Published: 26 April 2013
Cited by 31 | PDF Full-text (1061 KB) | HTML Full-text | XML Full-text
Abstract
Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs) are
[...] Read more.
Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs) are frequent events. The current dogma of RNA function describes mRNA to be responsible for the synthesis of proteins, whereas non-coding RNA can have regulatory or epigenetic functions. However, this distinction between protein coding and regulatory ability of transcripts may not be that strict. Here, we review the increasing body of evidence for the existence of multifunctional RNAs that have both protein-coding and trans-regulatory roles. Moreover, we demonstrate that coding transcripts bind to components of the Polycomb Repressor Complex 2 (PRC2) with similar affinities as non-coding transcripts, revealing potential epigenetic regulation by mRNAs. We hypothesize that studies on the regulatory ability of disease-associated mRNAs will form an important new field of research. Full article
(This article belongs to the Special Issue Non-coding RNA and Cancer)
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