Inflammatory Bowel Disease and Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 665

Special Issue Editor


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Guest Editor
Department of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy
Interests: inflammatory bowel disease; ulcerative colitis; Crohn’s disease; advanced therapy; biological drugs; small molecules; non-invasive monitoring; endoscopy; histology; fecal calprotectin

Special Issue Information

Dear Colleagues,

Crohn's disease and ulcerative colitis are difficult-to-treat inflammatory bowel diseases (IBD). Uncontrolled inflammation, long-term disease and the onset of complications such as strictures or fistulas can expose patients with IBD to an increased risk of cancer. In recent decades, several efforts have been made to improve screening programs and develop new drugs and new tools for monitoring patients and reducing the risk of cancer. This Special Issue will focus on the association between IBD and cancer, providing a guidance for clinicians to use advanced therapies, improve patient disease control and prevent complications.

Dr. Ferdinando D'Amico
Guest Editor

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Keywords

  • inflammatory bowel disease
  • ulcerative colitis
  • Crohn’s disease
  • cancer
  • malignancy

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Published Papers (1 paper)

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Review

11 pages, 513 KiB  
Review
Management of Patients with IBD and History of Cancer
by Ilaria Faggiani, Sarah Bencardino, Mariangela Allocca, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Clelia Cicerone, Virginia Solitano, Laurent Peyrin-Biroulet, Silvio Danese and Ferdinando D’Amico
Cancers 2025, 17(7), 1057; https://doi.org/10.3390/cancers17071057 - 21 Mar 2025
Viewed by 390
Abstract
The use of advanced therapies, including biologics and small molecules, has become an established clinical practice for the treatment of moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). However, certain patient populations, such as those with a history of cancer, are often excluded [...] Read more.
The use of advanced therapies, including biologics and small molecules, has become an established clinical practice for the treatment of moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). However, certain patient populations, such as those with a history of cancer, are often excluded from clinical trials evaluating the efficacy and safety of these therapies. This exclusion has historically left clinicians with limited evidence to guide treatment decisions in this high-risk group. Nevertheless, emerging real-world data and updated guidelines increasingly support the safe use of advanced therapies in patients with a prior malignancy. Risk stratification and a multidisciplinary approach, including oncologist input, remain critical in optimizing patient outcomes by assessing both cancer recurrence risk and disease activity. This review aims to provide a comprehensive overview of the current evidence, address existing knowledge gaps, and offer practical insights for the management of IBD in patients with a history of cancer. Full article
(This article belongs to the Special Issue Inflammatory Bowel Disease and Cancers)
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