Metabolic Networks in Cancer
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 14795
To enhance the translational understanding of the role of metabolic networks in cancer, I would like to invite you to contribute your work to this Special Issue set out to collect new advances in and perspectives on this topic.
Cancer constitutes a system of tumor cells with a high metabolic plasticity in a dynamic microenvironment, including gradients of nutrients, pH, and pO2, as well as the interaction of different cell types. This plasticity requires the modulation of a metabolic network consisting of metabolites, biochemical pathways, and regulatory nodes.
The dynamic interactions of such metabolic modules can occur at different levels—namely, 1) in the extracellular context by tumors and their associated cells, such as immune, stem, and stromal cells, which release, sense, or use specific metabolites in the tumor; 2) at the intracellular level by the modulation of different metabolic pathways of the individual cell through the dynamic interplay of metabolites and enzymes. Within the scope of the cell’s genetic program, the resulting metabolic network regulates the growth, survival, and cellular destiny of specific functions, stemness, or metastatic processes.
Understanding the mechanisms underlying different metabolic networks is thus of translational importance for the tumor prognosis, dietary influences, and chemo-therapeutic responses of cells constituting the tumor. It is also essential for evaluating information obtained with metabolic diagnostics and imaging in the clinical setting.
This Special Issue aims to highlight these aspects at different cellular and preclinical levels. Original papers and reviews based on biochemistry, cell biology, molecular genetics, and modeling applied to cancers with their associated cells and also in a preclinical setting are highly welcomed.
Dr. Angela M. Otto
- Metabolic heterogeneity in a tumor microenvironment
- Metabolic crosstalk of different cell types in cancer
- Cellular metabolomics and metabolic modeling
- Metabolic imaging techniques of cancers
- Metabolic interactions with chemotherapeutic drugs
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.