Infectious Agents and Lymphoproliferative Disorders: Different Mechanisms to Drive Neoplastic Transformation
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 3782
Special Issue Editor
Special Issue Information
Dear Colleagues,
Although a link between infectious agents and neoplasia has been suggested for a long time, only in recent years has clear-cut evidence of such a close correlation been provided. In view of the relevance of the immune system in controlling infections as well as the role of (chronic) inflammation in the pathogenesis of neoplasias, lymphoproliferative disorders have been claimed to represent an intriguing model to exemplify the relationship with several infectious agents. Mechanisms involved in favoring neoplastic transformation can be either indirect, for instance, the role of Helicobacter Pylori in the pathogenesis of MALT lymphoma, or rather direct, such as the role of Human T Lymphotropic Virus I in Adult T Cell Leukemia. Among these two ends of the spectrum, a plethora of lymphoproliferative disorders underlying a pathogenetic role of infectious agents is reported in the literature. Both viral (either RNA viruses including HTLV, HCV or HIV or DNA viruses, such as Epstein–Barr Virus) and bacterial agents (H. Pylori or Chlamydia species) are included in this growing list. Interestingly, even a putative role for human endogenous retroviral (HERV) sharing has been recently advocated. A common feature of all these disorders is that an initial indolent coexistence, i.e., when several mechanisms are devised by agents to keep their status, at some point strongly impacts with further autonomous proliferation of lymphoid cells, ultimately leading to neoplastic growth and cancer development.
In this Special Issue, we are focusing on the updated definition of mechanisms of different infectious agents as lymphoid cancer makers and the possibility to counteract their action before overt lymphoproliferative transformation, thus blocking their ability to lead to an autonomous cell growth.
Prof. Dr. Renato Zambello
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Chronic Lymphoproliferative disorders
- Multiple Myeloma
- NK cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
