Current Concept and Management of Pediatric ATRTs
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 3226
Special Issue Editors
Interests: pediatric neurosurgery; congenital CNS malformations; neuro-oncology; developmental biology; spine and spinal cord tumors; spinal tumors
Special Issues, Collections and Topics in MDPI journals
Interests: pediatric neuro-oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atypical teratoid rhabdoid tumors (ATRTs) are one of the CNS tumors that affect primarily infants and young children. They are fast-growing, invasive tumors with a high propensity of CSF disseminations. ATRTs occur in every location of the brain and spinal cord and present with a high case mortality following current treatment moderlities.
Since the first description by Rorke in 1995, the histogenesis of ATRT has remained an enigma. Due to the expression of neural, epithelial, and mesenchymal markers, they likely derive from pluripotent fetal cells. Based on genetic and DNA methylation status and transcriptome profiles, ATRTs are further divided into three distinct molecular subgroups: ATRT-SHH, ATRT-TYR, and ATRT-MYC; further subclassifications have been proposed. The WHO Classification of the CNS tumors has included ATRTs in “Embryonal Tumors”. ATRTs are distinct from other embryonal tumors because of their clinical presentation, tumor location, imaging characteristics, and prognosis. ATRTs are often a surgical challenge when extirpating a deep-seated large vascular mass in young patients. They are often resistant to conventional chemotherapy. Radiation therapy, which is imperative, raises serious concerns around affecting the developing CNS of the young. Safe and effective therapeutic measures are desperately needed.
This Special Issue will highlight recent advances in the biological understanding and clinical management of ATRT, deriving from preclinical, translational and/or clinical investigations. The results of innovative diagnostic modalities (molecular and imaging) will be included. The descriptions of results of case series or multi-center group studies are encouraged for a better understanding of the clinical behavior of these tumors. Reports of advanced surgical techniques for resection and also adjuvant therapy including novel molecular-targeted therapy and/or immunotherapy are welcome.
Prof. Dr. Tadanori Tomita
Dr. Alicia C. Lenzen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
