GTPases in Cancers: Therapeutic Opportunities and Challenges
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".
Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1934
Special Issue Editors
Interests: cancer biology; small molecule; inflammation; immunity; drug
Special Issue Information
Dear Colleagues,
GTPases are critical molecular switches in cell functions. GTPases play crucial roles in multiple cellular physiological processes, such as cell signaling, cell cycle regulation, and maintenance of cell polarity. Their abnormal activation or inactivation is closely associated with the occurrence and development of various diseases. Currently, GTPases are being investigated for their roles in malignancies, neurodegenerative diseases and cardiomyopathies. GTPases are considered difficult to target.
However, with the recent approval of KRAS inhibitors for treating pancreatic cancer and other high-risk malignancies, there is a renewed importance in re-examining GTPases to define their roles in diverse cancer states and to develop novel therapeutic agents. This re-evaluation is expected to unveil specific functions of GTPases in various cancer types, providing a foundation for designing more effective treatment strategies and opening up new avenues for developing innovative treatment targets and drugs. Since the recent approval of KRAS inhibitors for the treatment of pancreatic and other higher risk malignancies, GTPases deserve a revisit to define their roles in diverse disease states and novel develop therapeutic agents.
In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.
Dr. Rakesh K. K. Singh
Dr. Kyu Kwang Kim
Guest Editors
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Keywords
- GTAPses
- cancer
- Alzheimer’s disease
- pulmonary diseases
- cardiovascular diseases
- cell cycle
- proliferation
- secretion machinery and proteins
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