Diversity and Biology of Cancer-Associated Fibroblasts and the Novel Targeting Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5768
Special Issue Editor
Interests: tumor microenvironments; cancer-associated fibroblasts; photoimmunotherapy; cell-targeted therapy; gastroenterological malignant tumors; esophageal cancer; esophageal surgery
Special Issue Information
Dear Colleagues,
Targeting tumor microenvironment for cancer therapy is now a particularly hot research topic as immunotherapy targeting immune checkpoint has emerged. Cancer-associated fibroblasts are one of the most abundant components in the cancer microenvironment and are a group of cells that strongly affect cancer cells and surrounding immunocompetent cells. In particular, strong involvement has been suggested in highly malignant gastrointestinal cancer and pancreatic cancer, and elucidation of CAFs is an urgent issue for overcoming intractable cancer.
However, although CAFs are present in the interstitial region within the tumor microenvironment, it is known that their cell populations are heterogeneous. For example, in pancreatic cancer, the presence of FAP-positive CAFs is pro-tumorigenic, and conversely, SMA-positive cells are reported to act against the development of pancreatic cancer. There may be organ specificity in the background, and as such, there are still many uncertainties about the heterogeneity of CAFs and their respective biology.
Against this background, targeting CAFs are currently one of the most promising treatments, which can be compatible not only with tumor growth suppression but also with immunotherapy. Furthermore, remodeling by the tumor microenvironment is expected to improve the drug delivery system. Thus, it is of great interest to see what new treatments are possible for what CAF groups, or how those treatments affect cancer suppression.
The scope and aim of this Special Issue is to clarify the heterogeneity of CAFs by a marker-based method, analyze each function for the growth and progression of cancer, and propose a new treatment method to determine the treatment methods that can be developed for each cell group.
Dr. Kazuhiro Noma
Guest Editor
Manuscript Submission Information
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Keywords
- cancer-associated fibroblasts
- tumorigenesis
- heterogeneity
- interaction
- immune system
- target therapy
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