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Cancers
Special Issues
Virus-Associated Cancers
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Virus-Associated Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Infectious Agents and Cancer".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 1596

Special Issue Editor

Dr. Peter C. Angeletti

E-Mail Website
Guest Editor
Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
Interests: DNA replication and maintenance of human papillomaviruses (HPVs)

Special Issue Information

Dear Colleauges,

Cancers invites authors to submit papers for a Special Issue on the topic of “Virus-Associated Cancers”. The key goals of this Special Issue are to share updated knowledge on tumor virus–host interactions, cell transformation and cancer mechanisms, biomarkers, diagnosis, and cancer therapies. Recent progress regarding the roles of viral coinfections with viruses, such as Polyomaviruses, HPVs, EBV, KSHV, and HIV in cancer development are topics appropriate for this Special Issue. The role of the bacterial microbiome in relation to inflammation, tumor niche, and virally caused cancers would be of interest for this Special Issue. Manuscripts describing mechanistic, epidemiological, or clinical cancer studies, particularly in Low-Middle-Income-Countries (LMICs) are relevant for this Special Issue. The journal will consider original research or review articles.

Dr. Peter C. Angeletti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cervical cancer
  • oral cancer
  • squamous cell carcinoma
  • human papillomavirus (HPV)
  • polyomavirus (PyV)
  • Epstein–Barr virus (EBV)
  • Kaposi’s sarcoma herpes virus (KSHV)
  • human immunodeficiency virus (HIV)
  • inflammation
  • microbiome biomarkers
  • cancer therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 1647 KiB  
Article
Evaluation of Automatic Signal Detection of In Situ Hybridization for Detecting HPV DNA in Cervical Tissue Derived from Patients with Cervical Intraepithelial Neoplasia
by Marcin Przybylski, Sonja Millert-Kalińska, Mateusz de Mezer, Monika Krzyżaniak, Paweł Kurzawa, Jakub Żurawski, Robert Jach and Dominik Pruski
Cancers 2024, 16(20), 3485; https://doi.org/10.3390/cancers16203485 - 15 Oct 2024
Viewed by 1177
Abstract
Background: Cervical cancer is fourth the most common cancer in women worldwide. Due to the prevalence of human papillomavirus (HPV) in the population (80–90%), scientists are likely to discover even more associations of this pathogen with other diseases in the future. In recent [...] Read more.
Background: Cervical cancer is fourth the most common cancer in women worldwide. Due to the prevalence of human papillomavirus (HPV) in the population (80–90%), scientists are likely to discover even more associations of this pathogen with other diseases in the future. In recent years, In Situ Hybridization (ISH) assays that use automated signal-detecting methods in formalin-fixed, paraffin-embedded (FFPE) cervical tissue, such as the enzyme-categorized signal-detecting system, have shown a higher sensitivity. Objectives and Methods: To evaluate automatic signal detection of ISH assay for detecting HPV DNA, we compared the ability of an ISH probe, Inform HPV II and III (Ventana Medical Systems, Tucson, AZ), to that of PCR assays to detect HPV DNA in cervical tissue specimens with cervical intraepithelial neoplasia (CIN; CIN 1, 28 cases; CIN 2, 22 cases; and CIN 3, 20 cases) and normal cervix (2 cases). Results: Our findings showed a significant relation was confirmed between ISH III level and HPV outcome (positive/negative). Patients with positive HPV outcomes had significantly lower ISH III levels, MD = −7961.82 CI95 [−17,230.00; −199.21], p = 0.005. Conclusions: Automatic signal detection of ISH assay is not particularly applicable to cervical tissue material. A more useful method of confirming the presence of HPV in the cervix is the HPV test with genotyping, as it allows for collecting a larger amount of material from the cervical disc and canal. The interpretation of a positive or negative ISH test must be guided in the context of clinical history and morphology. Full article
(This article belongs to the Special Issue Virus-Associated Cancers)
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