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Cancers
Special Issues
Recent Advances in Diagnosis and Management of Colorectal Cancer
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Recent Advances in Diagnosis and Management of Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2644

Special Issue Editors

Dr. Shing Wai Wong

E-Mail Website
Guest Editor
1. School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, Australia
2. Department of General Surgery, Prince of Wales Hospital, Sydney, NSW, Australia
Interests: robotics; laparoscopy; ergonomics; learning curves; colonoscopy; surgical resection
Dr. Stephen Thompson

E-Mail Website
Guest Editor
1. Nelune Comprehensive Cancer Centre, Prince of Wales Hospital, Sydney, NSW, Australia
2. School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, Australia
Interests: radiation therapy; cancer treatment; brachytherapy; anal cancer; sarcoma
Dr. Zhen Hao Ang

E-Mail Website
Guest Editor
1. School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, Australia
2. Department of General Surgery, Prince of Wales Hospital, Sydney, NSW, Australia
Interests: robotics; ergonomics; learning curves; colorectal surgical resection; colorectal cancer treatment

Special Issue Information

Dear Colleagues,

We invite you to submit an original or a review article to this Special Issue on “Recent advances in Diagnosis and Management of Colorectal Cancer”. Advances in our pathophysiological understanding have led to improvements in the management of colorectal cancer (CRC). These advances encompass endoscopic excision, laparoscopic and robotic surgery, extended lymph node excision, navigational surgery, downstaging neoadjuvant radiotherapy, and chemotherapy, including toral neoadjuvant chemotherapy (TNT), targeted therapy, and immunotherapy. Other emerging research involving CRC comprises biomarkers, screening, artificial intelligence, gut microbiota, personalized therapy, management of metastatic disease, and genetics. The scope of this Special Issue of Cancers is to disseminate research related to the advances in the diagnosis and management of CRC. We look forward to including your submissions in this Special Issue to enhance our understanding of this common cancer.

Dr. Shing Wai Wong
Dr. Stephen Thompson
Dr. Zhen Hao Ang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • diagnosis
  • management
  • screening
  • surgery
  • radiotherapy
  • chemotherapy
  • immunotherapy
  • robotics
  • targeted therapy
  • prevention
  • prognosis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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18 pages, 1847 KiB  
Article
Treatment Quality of Rectal Cancer Patients in Certified Colorectal Cancer Centers Versus Non-Certified Hospitals: A Comparative Analysis
by Paweł Mroczkowski, Henry Kusian, Olof Jannasch, Hans Lippert, Radosław Zajdel, Karolina Zajdel, Arkadiusz Sadowski and Anna Merecz-Sadowska
Cancers 2025, 17(1), 120; https://doi.org/10.3390/cancers17010120 - 2 Jan 2025
Viewed by 839
Abstract
Background/Objectives: The certification of hospitals as colorectal cancer centers aims to improve treatment quality, but evidence supporting its effectiveness remains limited. This study evaluated the impact of certification on treatment outcomes for rectal cancer patients in Germany. Methods: We conducted a [...] Read more.
Background/Objectives: The certification of hospitals as colorectal cancer centers aims to improve treatment quality, but evidence supporting its effectiveness remains limited. This study evaluated the impact of certification on treatment outcomes for rectal cancer patients in Germany. Methods: We conducted a retrospective analysis of 14,905 patients with primary rectal cancer (UICC Stages I-III) treated at 271 hospitals. Treatment outcomes were compared between certified colorectal cancer centers (3624 patients in 55 hospitals) and non-certified hospitals (11,281 patients in 216 hospitals). Additionally, a subset analysis examined outcomes before and after certification within the same institutions. Results: Certified centers demonstrated higher utilization of preoperative imaging (endorectal ultrasound: 70.7% vs. 58.2%, p < 0.001; pelvic MRI: 39.1% vs. 28.5%, p < 0.001) and lower rates of intraoperative complications (4.6% vs. 6.2%, p < 0.001). Surgical quality indicators, including M.E.R.C.U.R.Y. classification (Grade 1: 86.5% both groups, p = 0.620) and anastomotic leakage rates (11.3% vs. 11.9%, p = 0.407), were comparable between certified and non-certified hospitals. Despite treating patients with more favorable tumor stages, certified centers showed no significant advantage in 5-year overall survival (82.8% vs. 82.0%, p = 0.880) or 30-day mortality (2.6% both groups, p = 0.869). Hospital stays were marginally shorter in certified centers (19.46 vs. 20.24 days, p < 0.001). Conclusions: While certification was associated with improved adherence to diagnostic protocols and reduced intraoperative complications, it did not significantly impact surgical quality or long-term survival outcomes. These findings suggest that certification alone may not guarantee superior treatment quality, as hospitals participating in quality assurance programs achieved comparable results without formal certification. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Management of Colorectal Cancer)
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13 pages, 2311 KiB  
Article
The Diagnosis and Evolution of Patients with LARS Syndrome: A Five-Year Retrospective Study from a Single Surgery Unit
by Cosmin Vasile Obleagă, Sergiu Marian Cazacu, Tiberiu Ștefăniță Țenea Cojan, Cecil Sorin Mirea, Dan Nicolae Florescu, Cristian Constantin, Mircea-Sebastian Șerbănescu, Mirela Marinela Florescu, Liliana Streba, Dragoș Marian Popescu, Ionică Daniel Vîlcea and Mihai Călin Ciorbagiu
Cancers 2024, 16(24), 4175; https://doi.org/10.3390/cancers16244175 - 14 Dec 2024
Cited by 1 | Viewed by 1284
Abstract
Objectives: The aim of the study was to assess the diagnosis and evolution of low anterior rectal resection syndrome (LARS) in patients admitted to a tertiary surgical center in Romania. Materials and Methods: From 120 patients initially included in the analysis, after applying [...] Read more.
Objectives: The aim of the study was to assess the diagnosis and evolution of low anterior rectal resection syndrome (LARS) in patients admitted to a tertiary surgical center in Romania. Materials and Methods: From 120 patients initially included in the analysis, after applying the exclusion criteria, we selected 102 patients diagnosed and operated on for neoplasm of the upper, middle, and lower rectum for which resection and excision (partial or total) of mesorectum was associated. All the patients we treated in the general surgery department of the County Emergency Hospital of Craiova within a time frame of 5 years (1 October 2017–1 September 2022), and all experienced at least one symptom associated with LARS. The group included 68 men and 34 women aged between 35 and 88, who were followed-up for at least 2 years. Patients with progression of neoplastic disease, with advanced neurological disease, and those who died less than 2 years after surgery were excluded. Results: The overall incidence varied by gender, site of the tumor (requiring a certain type of surgery), and anastomotic complications, and it was directly proportional to the time interval between resection and restoration of continuity of digestion. Conclusions: Obesity, size of the remaining rectum, total excision of the mesorectum, anastomotic complications, and prolonged ileostomy time are cofactors in the etiology of LARS. The LARS score decreased in most patients during the 2-year follow-up, although there were a small number of patients in whom the decrease was insignificant. The persistence of major LARS at 6 months after surgery may predict the need for a definitive colostomy. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Management of Colorectal Cancer)
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Review

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16 pages, 3731 KiB  
Review
Management of the Malignant Rectal Polyp—A Narrative Review
by Zhen Hao Ang and Shing Wai Wong
Cancers 2025, 17(9), 1464; https://doi.org/10.3390/cancers17091464 - 27 Apr 2025
Viewed by 183
Abstract
Purpose: The aim of this review is to provide a contemporary update on the current management approaches and options with specific considerations in malignant rectal polyps. Methods: A literature review was carried out in PubMed, Embase and Cochrane databases using the keywords “malignant” [...] Read more.
Purpose: The aim of this review is to provide a contemporary update on the current management approaches and options with specific considerations in malignant rectal polyps. Methods: A literature review was carried out in PubMed, Embase and Cochrane databases using the keywords “malignant” and “polyp*”. Only publications in English language were included. Results: Histopathological features including margins, depth of invasion, tumour grade, LVI and tumour budding determines the risk of lymph node metastasis in malignant polyps. Rectal malignant polyps should be considered differently compared to their colonic counterpart. A low threshold should be considered for utilising transrectal excision to fully excise the polyp and to assess the margins. The rates of complete pathological response associated with total neoadjuvant therapy as well as the advent of “watch and wait” adds to the complexity of managing malignant rectal polyps. Conclusions: The management of malignant colorectal polyps lies in risk-stratifying patients who will benefit from an oncological resection. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Management of Colorectal Cancer)
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