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Cancers
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Advances in Surgical Endoscopy for Upper GI Cancers
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Advances in Surgical Endoscopy for Upper GI Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 2413

Special Issue Editor

Prof. Dr. Christian Alexander Gutschow

E-Mail Website
Guest Editor
Department of Visceral Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland
Interests: upper GI surgery; minimally invasive surgery; complication management; surgical technique; robotic surgery

Special Issue Information

Dear Colleagues,

Endoscopic techniques have revolutionized the treatment of malignant diseases of the upper gastrointestinal tract and have become an indispensable part of clinical routine. In this context, interventional procedures for early-stage cancers and minimally invasive surgical techniques for advanced tumors both allow for curative treatment with minimal surgical trauma. The introduction of robotics in recent years has given a further boost to this development. Another domain of endoscopic procedures has become the treatment of postoperative complications such as anastomotic leaks; open surgical revisions, feared due to their high morbidity, are now required only in exceptional cases. Although all of these techniques have become the standard of care, they continue to evolve.

For this Special Issue of Cancers, manuscripts are welcome that present original data and updated literature reviews in the field of surgical endoscopy for malignancies of the upper digestive tract.

Prof. Dr. Christian Alexander Gutschow
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endoscopy
  • surgery
  • esophagus
  • stomach
  • anastomotic leakage
  • early carcinoma
  • robotic surgery
  • upper GI

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Published Papers (1 paper)

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11 pages, 3308 KiB  
Systematic Review
Efficacy and Safety of Cryoablation in Barrett’s Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis
by Apostolis Papaefthymiou, Benjamin Norton, Andrea Telese, Daryl Ramai, Alberto Murino, Paraskevas Gkolfakis, John Vargo and Rehan J. Haidry
Cancers 2024, 16(17), 2937; https://doi.org/10.3390/cancers16172937 - 23 Aug 2024
Cited by 3 | Viewed by 2047
Abstract
Background: The mainstay approach in endoscopic eradication therapy (EET) for dysplastic Barrett’s esophagus (BE) includes the endoscopic resection of visible lesions, accompanied by ablation of the residual metaplastic epithelium. Cryoablation therapy is one such emerging ablation technique in this field. This systematic review [...] Read more.
Background: The mainstay approach in endoscopic eradication therapy (EET) for dysplastic Barrett’s esophagus (BE) includes the endoscopic resection of visible lesions, accompanied by ablation of the residual metaplastic epithelium. Cryoablation therapy is one such emerging ablation technique in this field. This systematic review with a meta-analysis aims to accumulate pooled data on cryoablation performance in the treatment of patients with BE and to compare this technique to the standard of care radiofrequency ablation (RFA). Methods: The MEDLINE, Cochrane, and Scopus databases were searched until June 2024 for studies evaluating BE management using cryoablation for cumulative results. The primary outcome was the complete eradication of dysplasia (CED) and intestinal metaplasia (CEIM) in BE compared to RFA, while secondary outcomes included the respective pooled rates using cryoablation, recurrence, and adverse events, with a separate analysis for strictures. The meta-analyses were based on a random-effects model, and the results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analyses by type of cryoablation were also performed. Results: Twenty-three studies (1604 patients) were finally included, four of which were comparative. CED and CEIM did not differ significantly between cryoablation and RFA [OR= 0.95 (95%CI: 0.50–1.81) and OR = 0.57 (95%CI: 0.20–1.63), respectively)]. The pooled rates of CED, CEIM, and recurrence after cryoablation were 84.2% (95%CI: 79.1–89.3), 64.1% (95%CI: 49.2–79.0), and 8.3% (95%CI: 4.7–11.9), accompanied by high rates of heterogeneity. Adverse events were noted in 14.5% (95%CI: 9.9–19.2) of cases, and 6.5% (95%CI: 4.1–9.0) developed strictures. In the subgroup analysis, the cryoballoon achieved a reduction in heterogeneity in CED, adverse events, and stricture formation, whereas spray catheters provided homogenous results in terms of recurrence. Conclusions: Cryoablation provides equal outcomes compared to RFA in the treatment of patients with BE, with the cryoballoon achieving relatively homogenous rates of CED and adverse events. Full article
(This article belongs to the Special Issue Advances in Surgical Endoscopy for Upper GI Cancers)
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