Prostate Cancer Epidemiology and Lifestyle Factors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (1 February 2024) | Viewed by 2743

Special Issue Editor


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Guest Editor
Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA
Interests: cancer epidemiology; genetics, environmental and lifestyle risk factors of prostate cancer

Special Issue Information

Dear Colleagues,

Prostate cancer (PrCa) is the most commonly diagnosed solid tumor and the second leading cause of cancer deaths among men in the Western world. This is a multi-factorial disease with a complex etiology, where both genetic and environmental factors contribute to the risk. The well-established risk factors for this cancer are increasing age, race/ethnicity and family history of PrCa. Among lifestyle factors, the most putative risk factors are obesity/BMI, cigarette smoking and some dietary factors. 

The goal of the Special Issue is to solicit manuscripts that summarize the evidence of the role of lifestyle factors, such as BMI/obesity, physical activity, cigarette smoking and dietary factors, as well as occupational and other environmental factors of risks for both total PrCa, as well as more aggressive phenotypes as determined by a higher Gleason score, advanced tumor stage or fatal PrCa. Of special interest will be studies conducted in many different populations, particularly among high-risk men, including men of African descent or Hispanic/Latinos. Studies in such populations are currently missing from the literature. Of interest will be also studies that link both genetic and lifestyle or dietary factors to PrCa etiology. In addition, we encourage the submission of biomarker studies that explore mediation and explain the link between lifestyle, diet and PrCa risk.  Finally, meta-analyses of studies on lifestyle and environmental risk factors and PrCa etiology are encouraged, but these need to provide additional details that are lacking from the current literature and move the field forward.

Dr. Ilir Agalliu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • epidemiology
  • lifestyle
  • risk factors
  • etiology

Published Papers (2 papers)

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Research

15 pages, 582 KiB  
Article
Distinct Prostate Cancer Survival Outcomes in Firefighters: A Population-Based Study
by Paulo S. Pinheiro, Tulay Koru-Sengul, Wei Zhao, Diana R. Hernandez, Monique N. Hernandez, Erin N. Kobetz, Alberto J. Caban-Martinez and David J. Lee
Cancers 2024, 16(7), 1305; https://doi.org/10.3390/cancers16071305 - 27 Mar 2024
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Abstract
Introduction: Survival outcomes for prostate cancer among specific occupational groups prone to regular medical check-ups vis-à-vis the general population have been understudied. For firefighters, a demographic subject to rigorous medical evaluations, possessing above-average medical expertise, and exposed to specific carcinogens of interest, prostate [...] Read more.
Introduction: Survival outcomes for prostate cancer among specific occupational groups prone to regular medical check-ups vis-à-vis the general population have been understudied. For firefighters, a demographic subject to rigorous medical evaluations, possessing above-average medical expertise, and exposed to specific carcinogens of interest, prostate cancer survival in the US has never been studied. Methods: We conducted a retrospective study, utilizing data from the Florida Cancer Data System spanning 2004 to 2014, coupled with firefighter certification records from the Florida State Fire Marshal’s Office. Our study cohort consisted of 1058 prostate cancer cases among firefighters as well as prostate cases for the Florida general population (n = 150,623). We compared cause-specific survival between the two using Cox regression models adjusted for demographics and clinical characteristics, including PSA levels, Gleason scores, and treatment modalities. Results: Firefighters demonstrated a higher five-year cause-specific survival rate (96.1%, 95% CI: 94.7–97.1%) than the general population (94.2%, 95%CI: 94.1–94.3%). Overall, firefighters’ diagnoses were established at younger ages (median age 63 vs. 67 in the general population), exhibited a higher proportion of localized stage cancers (84.7% vs. 81.1%), and had a greater utilization of surgery (46.4% vs. 37.6%), a treatment modality with a high success rate but potential side effects. In multivariable analysis, firefighters displayed a survival advantage for localized stage (adjusted hazard ratio [aHR] = 0.53; 95%CI: 0.34–0.82). However, for regional or distant stages, firefighters aged 65 and above exhibited a higher risk of death (aHR = 1.84; 95% CI: 1.18–2.86) than the general population. Conclusion: Firefighters experience enhanced prostate cancer survival, primarily in cases diagnosed at localized stages, likely due to increased PSA testing. Nonetheless, for regional or distant stage, survival among older firefighters’ lags behind that of the general population. Further investigations are warranted to unravel factors influencing the development of aggressive disease beyond PSA and Gleason scores in this population, as well as to assess the impact of a higher rate of surgical treatment on firefighters’ quality of life. Full article
(This article belongs to the Special Issue Prostate Cancer Epidemiology and Lifestyle Factors)
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14 pages, 311 KiB  
Article
Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study
by Enrique Almanza-Aguilera, Daniel Guiñón-Fort, Aurora Perez-Cornago, Miriam Martínez-Huélamo, Cristina Andrés-Lacueva, Anne Tjønneland, Anne Kirstine Eriksen, Verena Katzke, Rashmita Bajracharya, Matthias B. Schulze, Giovanna Masala, Andreina Oliverio, Rosario Tumino, Luca Manfredi, Cristina Lasheras, Marta Crous-Bou, Maria-José Sánchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Emily Sonestedt, Anders Bjartell, Elin Thysell, Elisabete Weiderpass, Dagfinn Aune, Elom K. Aglago, Ruth C. Travis and Raul Zamora-Rosadd Show full author list remove Hide full author list
Cancers 2023, 15(16), 4067; https://doi.org/10.3390/cancers15164067 - 11 Aug 2023
Cited by 2 | Viewed by 1268
Abstract
Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the [...] Read more.
Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence. Full article
(This article belongs to the Special Issue Prostate Cancer Epidemiology and Lifestyle Factors)
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