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Advances in Spinal Tumoral Pathology: Surgical Perspectives and Multidisciplinary Therapeutic Approaches

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: closed (20 July 2025) | Viewed by 856

Special Issue Editor


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Guest Editor
1. Department of Neurosurgery, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania
2. Department of Neurosurgery, Cluj County Clinical Emergency Hospital Cluj-Napoca, Cluj-Napoca, Romania
Interests: neuro-oncology; neurovascular surgery; skull base surgery; trauma; pediatric neurosurgery
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Special Issue Information

Dear Colleagues,

This Special Issue, titled “Advances in Spinal Tumoral Pathology: Surgical Perspectives and Multidisciplinary Therapeutic Approaches", aims to delve into the latest developments in surgical approaches to managing spinal tumors. Featuring contributions from leading experts in neurosurgery and oncology, this Special Issue explores innovative techniques, technologies, and outcomes in the field. Articles cover a range of topics, including minimally invasive procedures, image-guided surgery, spinal stabilization methods, and advancements in tumor resection. Additionally, this Special Issue aims to examine emerging trends such as personalized treatment plans based on genetic profiling or the integration of adjuvant therapies to improve patient outcomes. Through comprehensive reviews, case studies, and clinical insights, this Special Issue offers valuable perspectives for clinicians, researchers, and healthcare professionals involved in the multidisciplinary care of patients with spinal tumors, providing a vital resource for staying abreast of the latest advancements in this complex and evolving field.

Ultimately, this Special Issue underscores the paramount importance of patient quality of life as a primary outcome goal, reflecting a comprehensive approach to surgical interventions for spinal tumors.

Prof. Dr. Ştefan Florian
Guest Editor

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Keywords

  • spinal tumors
  • oncological surgery
  • spinal oncology
  • minimally invasive techniques
  • multidisciplinary treatment
  • targeted therapy
  • patient outcomes in spinal surgery
  • imagine techniques in spinal tumors
  • surgical robotics in spinal tumor resection
  • neuromonitoring

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Published Papers (1 paper)

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Research

17 pages, 5242 KB  
Article
Spinal Metastasis from Supratentorial Glioblastoma: A Registry-Based Case Series and a Review of the Literature
by Arthur Chak Kai Lau, Desiree Ka-ka Wong, Justin Chun Him Cheung, Candice H. W. Lam, Myron Chak Him Wong, Jason Chak Yan Li, Danny T. M. Chan, Herbert H. F. Loong, Michael W. Y. Lee, Tony K. T. Chan, Jason M. K. Ho, Ka-Man Cheung, Teresa P. K. Tse, Joyce S. W. Chow, Aya El-Helali and Peter Y. M. Woo
Cancers 2025, 17(18), 2979; https://doi.org/10.3390/cancers17182979 - 12 Sep 2025
Viewed by 430
Abstract
Background: Spinal metastasis is a rare complication of supratentorial glioblastoma. We report the clinical features and prognosis of this phenomenon and review the relevant literature. Methods: This is a territory-wide, multicentre, retrospective review using data from the Hong Kong High-grade Glioma [...] Read more.
Background: Spinal metastasis is a rare complication of supratentorial glioblastoma. We report the clinical features and prognosis of this phenomenon and review the relevant literature. Methods: This is a territory-wide, multicentre, retrospective review using data from the Hong Kong High-grade Glioma Registry from 2006 to 2023. Data of consecutive adult patients diagnosed with supratentorial glioblastoma and spinal metastasis were extracted and analyzed. Results: Among the 1342 patients with supratentorial glioblastoma, 15 were diagnosed to have spinal metastasis (1.1%). The median time to spinal metastasis from the initial diagnosis of glioblastoma was 38.7 weeks (IQR: 15.1–57.6). Multi-level spinal involvement was present in 60% (9/15) of patients. Neither the topographical location of the tumor in relation to the subventricular zone, extent of resection, occurrence of intraoperative ventricular entry, nor methylguanine methyltransferase (MGMT) promoter methylation status predicted the time to spinal metastasis. The median overall survival was 44.1 weeks (IQR: 29.9–80.2), and the median post-spinal metastasis survival was 12.6 weeks (IQR: 5.0–15.0). Two-thirds of patients received spinal radiotherapy, 26.7% had systemic therapy (chemotherapy, targeted therapy, and/or immunotherapy), and 13.3% underwent surgical spinal decompression. No significant survival improvement was observed among patients who received spinal radiotherapy (HR: 0.61; 95% CI: 0.17–2.23) or systemic therapy (HR: 0.94; 95% CI: 0.20–4.39). Conclusions: This case series illustrates the management practices and clinical course of glioblastoma patients with spinal metastasis. No treatment modality was proven to be superior. Treatment remains largely palliative and should be tailored on an individual basis. Full article
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